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- Title
A Nutraceutical Containing Chlorogenic Acid and Luteolin Improves Cardiometabolic Parameters in Subjects with Pre-obesity: A 6-Month Randomized, Double-Blind, Placebo-Controlled Study.
- Authors
Terzo, Simona; Amato, Antonella; Magán-Fernández, Antonio; Castellino, Giuseppa; Calvi, Pasquale; Chianetta, Roberta; Giglio, Rosaria V.; Patti, Angelo M.; Nikolic, Dragana; Firenze, Alberto; Mulè, Flavia; Ciaccio, Marcello; Rizzo, Manfredi
- Abstract
Pre-obesity is a condition that predisposes to the risk of developing obesity, cardiovascular diseases (CVD), and diabetes. Our previous study demonstrated that a Cynara cardunculus (L.) based nutraceutical named Altilix® (Bionap, Italy), containing chlorogenic acid and luteolin extracts, was able to improve several hepatic and cardio-metabolic parameters. Given this background, we conducted a post-hoc analysis of the Altilix® study in order to analyze the supplement's effects in the subgroup of pre-obesity subjects on anthropometry (weight and waist circumference), glucose metabolism (HbA1C, HOMA-IR, and HOMA-β), lipid profile (total cholesterol, triglycerides, LDL-cholesterol and HDL-cholesterol), hepatic functionality (FLI, AST, ALT and AST/ALT), carotid-media thickness (CIMT) and endothelial function (FMD). Fifty subjects from the original study cohort (which consisted of 100 subjects) were chosen with BMI ≥ 25 and < 30 kg/m2. All subjects received the Altilix® supplement (150 mg/day) or placebo using a computer-based random allocation system. After six months of treatment Altilix® significantly reduced body weight, glycemic, and lipid parameters (total cholesterol, triglycerides, LDL-cholesterol) and improved hepatic functionality, CIMT, and FMD. In conclusion, these results confirm that Altilix® supplementation has a significant effect on cardiometabolic parameters not only in obese subjects but also in pre-obesity subjects.
- Subjects
FUNCTIONAL foods; CARDIOVASCULAR diseases risk factors; STATISTICS; ACIDS; ANTHROPOMETRY; BLOOD sugar; DIETARY supplements; FLAVONES; BLIND experiment; DATA analysis
- Publication
Nutrients, 2023, Vol 15, Issue 2, p462
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu15020462