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- Title
Adzuki Bean MY59 Extract Reduces Insulin Resistance and Hepatic Steatosis in High-Fat-Fed Mice via the Downregulation of Lipocalin-2.
- Authors
Lee, Jaewoong; Lee, Byong Won; Kim, Kyung Eun; An, Hyeong Seok; Jeong, Eun Ae; Shin, Hyun Joo; Song, Seok Bo; Roh, Gu Seob
- Abstract
Adzuki bean is well known as a potential functional food that improves metabolic complications from obesity and diabetes. Lipocalin-2 (LCN2) has been implicated to have an important role in obesity and diabetes. However, the protective roles of adzuki bean MY59 extract (ABE) on insulin resistance and hepatic steatosis are not fully understood. In the present study, we investigated the effects of ABE on LCN2 expression in high-fat diet (HFD)-fed mice. ABE reduced HFD-induced fat mass and improved insulin resistance. In addition to hepatic steatosis, HFD-fed mice showed many apoptotic cells and neutrophils in the epididymal fat pads. However, these findings were significantly reduced by ABE supplementation. In particular, we found that increased LCN2 proteins from serum, epididymal fat pads, and liver in HFD-fed mice are significantly reduced by ABE. Furthermore, ABE reduced increased heme oxygenase-1 and superoxide dismutase-1 expressions in adipose tissue and liver in HFD-fed mice. We found that hepatic nuclear factor-kappa B (NF-κB) p65 expression in HFD-fed mice was also reduced by ABE. Thus, these findings indicate that ABE feeding could improve insulin resistance and hepatic steatosis by decreasing LCN2-mediated inflammation and oxidative stress in HFD-fed mice.
- Subjects
BIOLOGICAL models; ACUTE phase proteins; FATTY liver; ANIMAL experimentation; OXIDATIVE stress; PLANT extracts; INSULIN resistance; MICE
- Publication
Nutrients, 2022, Vol 14, Issue 23, p5049
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu14235049