We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Curcumin-Added Whey Protein Positively Modulates Skeletal Muscle Inflammation and Oxidative Damage after Exhaustive Exercise.
- Authors
Dias, Kelly Aparecida; da Conceição, Aline Rosignoli; Pereira, Stephanie Michelin Santana; Oliveira, Lívya Alves; da Silva Rodrigues, João Vitor; Dias, Roberto Sousa; de Paula, Sérgio Oliveira; Natali, Antônio José; da Matta, Sérgio Luis Pinto; Gonçalves, Reggiani Vilela; Tako, Elad; Martino, Hercia Stampini Duarte; Lucia, Ceres Mattos Della
- Abstract
(1) Background: Exhaustive exercise can induce muscle damage. The consumption of nutritional compounds with the ability to positively influence the oxidative balance and an exacerbated inflammatory process has been previously studied. However, little is known about the nutritional value of curcumin (CCM) when mixed with whey protein concentrate (WPC). This study was developed to evaluate the effect of CCM-added WPC on inflammatory and oxidative process control and histopathological consequences in muscle tissue submitted to an exhaustive swimming test (ET). (2) Methods: 48 animals were randomly allocated to six groups (n = 8). An ET was performed 4 weeks after the start of the diet and animals were euthanized 24 h post ET. (3) Results: WPC + CCM and CCM groups reduced IL-6 and increased IL-10 expression in muscle tissue. CCM reduced carbonyl protein after ET compared to standard AIN-93M ET and WPC + CCM ET diets. Higher nitric oxide concentrations were observed in animals that consumed WPC + CCM and CCM. Consumption of WPC + CCM or isolated CCM reduced areas of inflammatory infiltrate and fibrotic tissue in the muscle. (4) Conclusions: WPC + CCM and isolated CCM contribute to the reduction in inflammation and oxidative damage caused by the exhaustive swimming test.
- Subjects
INFLAMMATION prevention; INTERLEUKINS; SKELETAL muscle; ANIMAL experimentation; CURCUMIN; EXERCISE physiology; OXIDATIVE stress; GENE expression; COMPARATIVE studies; DESCRIPTIVE statistics; NITRIC acid; WHEY proteins; SWIMMING
- Publication
Nutrients, 2022, Vol 14, Issue 22, p4905
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu14224905