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- Title
Assessment of SARS-CoV-2 Infection According to Previous Metabolic Status and Its Association with Mortality and Post-Acute COVID-19.
- Authors
de Arriba Fernández, Alejandro; Alonso Bilbao, José Luis; Espiñeira Francés, Alberto; Cabeza Mora, Antonio; Gutiérrez Pérez, Ángela; Díaz Barreiros, Miguel Ángel; Serra Majem, Lluís
- Abstract
Background. SARS-CoV-2 infection was analyzed according to previous metabolic status and its association with mortality and post-acute COVID-19. Methods. A population-based observational retrospective study was conducted on a cohort of 110,726 patients aged 12 years or more who were diagnosed with COVID-19 infection between June 1st, 2021, and 28 February 2022 on the island of Gran Canaria, Spain. Results. In the 347 patients who died, the combination of advanced age, male sex, cancer, immunosuppressive therapy, coronary heart disease, elevated total cholesterol and reduced high-density lipoprotein cholesterol (HDL-C) was strongly predictive of mortality (p < 0.05). In the 555 patients who developed post-acute COVID-19, the persistence of symptoms was most frequent in women, older subjects and patients with obstructive sleep apnea syndrome, asthma, elevated fasting glucose levels or elevated total cholesterol (p < 0.05). A complete vaccination schedule was associated with lower mortality (incidence rate ratio (IRR) 0.5, 95%CI 0.39–0.64; p < 0.05) and post-acute COVID-19 (IRR 0.37, 95%CI 0.31–0.44; p < 0.05). Conclusions. Elevated HDL-C and elevated total cholesterol were significantly associated with COVID-19 mortality. Elevated fasting glucose levels and elevated total cholesterol were risk factors for the development of post-acute COVID-19.
- Subjects
SPAIN; BLOOD sugar analysis; HDL cholesterol; COVID-19; SCIENTIFIC observation; CONFIDENCE intervals; POST-acute COVID-19 syndrome; AGE distribution; COVID-19 vaccines; RETROSPECTIVE studies; ACQUISITION of data; RISK assessment; SEX distribution; MEDICAL records; DESCRIPTIVE statistics; CHOLESTEROL; DISEASE risk factors
- Publication
Nutrients, 2022, Vol 14, Issue 14, pN.PAG
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu14142925