We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Metabolic acidosis in the first 14 days of life in infants of gestation less than 26 weeks.
- Authors
Bourchier, David; Weston, Philip
- Abstract
Extremely immature newborns develop a self-limiting normal anion gap metabolic acidosis in early life. This study examined the natural history of this acidosis in a population of infants of gestation less than 26 weeks in the first 14 days of life. The acidosis was maximal on day 4 with a mean base deficit of 10.6 mmol/l and had resolved in 90 % of infants by day 11. Dopamine usage was the only independent predictor of the acidosis. Its use was associated with a greater degree of acidosis. Conclusion: Extremely preterm infants experience a self-limiting normal anion gap metabolic acidosis in the first 2 weeks of life which is consistent with renal tubular immaturity.
- Subjects
ACIDOSIS research; GESTATIONAL age; KIDNEY tubules; AMMONIUM ions; PHYSIOLOGICAL effects of dopamine; BLOOD gases analysis; PREMATURE infants; HEALTH
- Publication
European Journal of Pediatrics, 2015, Vol 174, Issue 1, p49
- ISSN
0340-6199
- Publication type
Article
- DOI
10.1007/s00431-014-2364-9