We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Therapeutic Potential of Mitophagy-Inducing Microflora Metabolite, Urolithin A for Alzheimer's Disease.
- Authors
Jayatunga, Dona Pamoda W.; Hone, Eugene; Khaira, Harjot; Lunelli, Taciana; Singh, Harjinder; Guillemin, Gilles J.; Fernando, Binosha; Garg, Manohar L.; Verdile, Giuseppe; Martins, Ralph N.
- Abstract
Mitochondrial dysfunction including deficits of mitophagy is seen in aging and neurodegenerative disorders including Alzheimer's disease (AD). Apart from traditionally targeting amyloid beta (Aβ), the main culprit in AD brains, other approaches include investigating impaired mitochondrial pathways for potential therapeutic benefits against AD. Thus, a future therapy for AD may focus on novel candidates that enhance optimal mitochondrial integrity and turnover. Bioactive food components, known as nutraceuticals, may serve as such agents to combat AD. Urolithin A is an intestinal microbe-derived metabolite of a class of polyphenols, ellagitannins (ETs). Urolithin A is known to exert many health benefits. Its antioxidant, anti-inflammatory, anti-atherogenic, anti-Aβ, and pro-mitophagy properties are increasingly recognized. However, the underlying mechanisms of urolithin A in inducing mitophagy is poorly understood. This review discusses the mitophagy deficits in AD and examines potential molecular mechanisms of its activation. Moreover, the current knowledge of urolithin A is discussed, focusing on its neuroprotective properties and its potential to induce mitophagy. Specifically, this review proposes potential mechanisms by which urolithin A may activate and promote mitophagy.
- Subjects
FUNCTIONAL foods; ALZHEIMER'S disease; AUTOPHAGY; GUT microbiome; INFLAMMATION; MITOCHONDRIA; CELLULAR signal transduction; OXIDATIVE stress; BENZOPYRANS; METABOLITES
- Publication
Nutrients, 2021, Vol 13, Issue 11, p3744
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu13113744