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- Title
Multiple Micronutrients, Including Zinc, Selenium and Iron, Are Positively Associated with Anemia in New Zealand Aged Care Residents.
- Authors
MacDonell, Sue O.; Miller, Jody C.; Harper, Michelle J.; Reid, Malcolm R.; Haszard, Jillian J.; Gibson, Rosalind S.; Houghton, Lisa A.; Lara, Jose
- Abstract
Anemia is a significant comorbidity for older adults not fully attributable to iron deficiency. Low-grade inflammation and other micronutrient deficiencies also contribute. This cross-sectional study examined the relationships between nutrient and non-nutrient factors with hemoglobin and anemia in 285 residents (>65 years) of 16 New Zealand aged-care facilities. Blood samples were analyzed for hemoglobin, ferritin, sTfR, hepcidin, zinc, selenium, and interleukin-6 (IL-6), (with ferritin, sTfR, zinc and selenium adjusted for inflammation). Linear regression models examined the relationships between micronutrient biomarkers (iron, zinc, selenium, vitamin B-12 and D), age, sex, and health factors with hemoglobin. Thirty-two percent of participants exhibited anemia, although <2% had either depleted iron stores or iron deficiency. Plasma zinc and selenium deficiencies were present in 72% and 38% of participants, respectively. Plasma zinc and total body iron (TBI) were positively associated (p < 0.05) with hemoglobin, while gastric acid suppressing medications, hepcidin, and interleukin-6 were inversely associated. These relationships were maintained after the application of anemia cut-offs. These findings emphasize the importance of considering multiple micronutrient deficiencies as risk factors for anemia.
- Subjects
NEW Zealand; INTERLEUKINS; HEMOGLOBINS; IRON; FERRITIN; REGRESSION analysis; NURSING care facilities; ANEMIA; DESCRIPTIVE statistics; MICRONUTRIENTS; ZINC; IRON deficiency anemia; ELDER care; SELENIUM; DISEASE risk factors
- Publication
Nutrients, 2021, Vol 13, Issue 4, p1072
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu13041072