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- Title
Sulforaphene Suppresses Adipocyte Differentiation via Induction of Post-Translational Degradation of CCAAT/Enhancer Binding Protein Beta (C/EBPβ).
- Authors
Yang, Hee; Kang, Min Jeong; Hur, Gihyun; Lee, Tae Kyung; Park, In Sil; Seo, Sang Gwon; Yu, Jae Gak; Song, Yong Sang; Park, Jung Han Yoon; Lee, Ki Won
- Abstract
Adipocyte differentiation (adipogenesis) is a crucial process that determines the total number and size of mature adipocytes that will develop. In this study, the anti-adipogenic effect of sulforaphene (SFEN), a dietary isothiocyanate (ITC) derived from radish, is investigated both in 3T3-L1 pre-adipocytes and in human adipose tissue-derived stem cells. The results revealed that SFEN significantly inhibit adipogenic cocktail-induced adipocyte differentiation and lipid accumulation at the early stage of adipogenesis. Additionally, the effects are more potent compared to those of other ITCs derived from various cruciferous vegetables. As a related molecular mechanism of action, SFEN promotes the post-translational degradation of CCAAT/enhancer-binding protein (C/EBP) β by decreasing the stability of C/EBPβ, which is responsible for decreasing the expression of master regulatory proteins such as peroxisome proliferator-activated receptor γ and C/EBPα. Collectively, these results suggest that the intake of SFEN-enriched natural materials could be helpful as a strategy for preventing obesity.
- Subjects
ADIPOSE tissues; CELL physiology; DEFICIENCY diseases; GENE expression; MOLECULAR structure; MUTAGENS; STEM cells; T-test (Statistics); WESTERN immunoblotting; PHYTOCHEMICALS; PLANT extracts
- Publication
Nutrients, 2020, Vol 12, Issue 3, p758
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu12030758