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- Title
Effects of prolactin on movement disorders and APOE, GFAP, and PRL receptor gene expression following intracerebral hemorrhage in rats.
- Authors
Yousefvand, Shiba; Hadjzadeh, Mousa-al-Reza; Keshavarzi, Zakieh; Dolatshad, Hamid; Vafaee, Farzaneh; Mahmoudabady, Maryam; Virany, Zahra Gholamzadeh
- Abstract
Objective(s): Intracerebral hemorrhage (ICH) occurs mostly in the striatum. In ICH, blood prolactin level increases 3-fold. The effects of intracerebroventricular injection (ICV) of prolactin on motor disorders will be investigated. Materials and Methods: This study was performed on 32 male Wistar rats in 4 groups: sham, ICH, and prolactin with 1 µg/2 µl (P1) and 2 µg/2 µl (P2) doses. Results: The weight of animals on days 1 (P=0.01), 3, and 7 (P=0.05) in the sham and P2 groups increased compared with the ICH group. Neurological Deficit Score (NDS) in ICH and P1 groups decreased, and increased compared with sham and ICH groups (P=0.001), respectively. NDS in the P1 group increased compared with the P2 group on days 1 (P=0.0 5), 3, and 7 (P=0.001). The duration time of rotarod in ICH and P1 groups decreased and increased compared with sham and ICH groups (P=0.001), respectively. The duration time of rotarod in the P1 group on days 3 and 7 increased compared with the P2 group (P=0.001). Travel distance in days 1(P=0.01), 3(P=0.001), and 7(P=0.01) decreased in the ICH group. Prolactin receptor (PRL receptor) expression in ICH, P1, and P2 groups increased compared with sham and ICH groups (P=0.001). Glial fibrillary acidic protein (GFAP) expression (P=0.001) and apolipoprotein E (APOE) (P=0.01) expression in the ICH group increased compared with the sham group. GFAP and APOE expression in the P1 group increased compared with the ICH group (P=0.001). APOE expression in the P1 group increased compared with the P2 group (P=0.001). Conclusion: According to the results, prolactin reduces movement disorders.
- Subjects
CEREBRAL hemorrhage; GLIAL fibrillary acidic protein; MOVEMENT disorders; APOLIPOPROTEIN E; GENE expression
- Publication
Iranian Journal of Basic Medical Sciences, 2021, Vol 24, Issue 12, p1709
- ISSN
2008-3866
- Publication type
Article
- DOI
10.22038/IJBMS.2021.58176.12927