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- Title
Effect of ischemic preconditioning on the expression of c-myb in the CA1 region of the gerbil hippocampus after ischemia/reperfusion injury.
- Authors
Hui Young Lee; Hyun-Jin Tae; Geum-Sil Cho; In Hye Kim; Jeong Hwi Cho; Joon Ha Park; Ji Hyeon Ahn; Bai Hui Chen; Bich-Na Shin; Moo-Ho Won; Chan Woo Park; Jun Hwi Cho; Jeong Yeol Seo; Jae-Chul Lee
- Abstract
Objective(s): In the present study, we investigated the effect of ischemic preconditioning (IPC) on c-myb immunoreactivity as well as neuronal damage/death after a subsequent lethal transient ischemia in gerbils. Materials and Methods: IPC was subjected to a 2 min sublethal ischemia and a lethal transient ischemia was given 5 min transient ischemia. The animals in all of the groups were given recovery times of 1 day, 2 days and 5 days and we examined change in c-myb immunoreactivity as well as neuronal damage/death in the hippocampus induced by a lethal transient ischemia. Results: A lethal transient ischemia induced a significant loss of cells in the stratum pyramidale (SP) of the hippocampal CA1 region at 5 days post-ischemia, and this insult showed that c-myb immunoreactivity in cells of the SP of the CA1 region was significantly decreased at 2 days postischemia and disappeared at 5 days post-ischemia. However, IPC effectively prevented the neuronal loss in the SP and showed that c-myb immunoreactivity was constitutively maintained in the SP after a lethal transient ischemia. Conclusion: Our results show that a lethal transient ischemia significantly decreased c-myb immunoreactivity in the SP of the CA1 region and that IPC well preserved c-myb immunoreactivity in the SP of the CA1 region. We suggest that the maintenance of c-myb might be related with IPCmediated neuroprotection after a lethal ischemic insult.
- Subjects
HIPPOCAMPUS (Brain); ISCHEMIA; REPERFUSION injury; ISCHEMIC preconditioning; MEDICAL care
- Publication
Iranian Journal of Basic Medical Sciences, 2016, Vol 19, Issue 6, p624
- ISSN
2008-3866
- Publication type
Article