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- Title
Is allogeneic stem cell transplantation for myelofibrosis still indicated at the time of molecular markers and JAK inhibitors era?
- Authors
Lestang, Elsa; Peterlin, Pierre; Le Bris, Yannick; Dubruille, Viviane; Delaunay, Jacques; Godon, Catherine; Theisen, Olivier; Blin, Nicolas; Mahe, Beatrice; Gastinne, Thomas; Garnier, Alice; Touzeau, Cyrille; Voldoire, Maud; Bene, Marie C.; Le Gouill, Steven; Milpied, Noel; Mohty, Mohamad; Moreau, Philippe; Guillaume, Thierry; Chevallier, Patrice
- Abstract
Objective The role of allogenic stem cell transplantation ( ASCT) is still debated in myelofibrosis (MF). Methods A retrospective analyzed was performed to compare the outcome of 71 patients with intermediate-2 or high-risk Dynamic International Prognosis Scoring System+ ( DIPSS+) primary ( PMF) or secondary ( SMF) myelofibrosis with an indication of ASCT as they ultimately underwent the procedure (n=34) or not (n=37). Results Five-year overall survival ( OS) was not statistically different between both groups (allograft: 52% vs no allograft: 34%, P=.12). However, progression to myelodysplastic syndrome or acute myeloid leukemia at 5 years was significantly lower in transplanted patients (14% vs 50%, P=.01). In univariate analysis, 5-year OS was significantly higher for transplanted vs non-transplanted patients with unfavorable karyotype (75% vs 0%, P=.001), SMF (71% vs 20%, P=.001) or high DIPSS+ score (46% vs 15%, P=.03). There was also a trend for better 5-year OS in allografted patients with high JAK2V617F burden (>65%) (75% vs 8%, P=.07). Interestingly, the survival of patients who did not proceed to ASCT was dramatically increased by the use of ruxolitinib. Conclusions Not all intermediate-2/high-risk DIPSS+ MF patients benefit from ASCT, especially since the introduction of JAK2 inhibitors.
- Subjects
STEM cell transplantation; MYELOFIBROSIS; JANUS kinases; MYELOPROLIFERATIVE neoplasms; DISEASE progression; ACUTE myeloid leukemia; THERAPEUTICS
- Publication
European Journal of Haematology, 2017, Vol 99, Issue 1, p60
- ISSN
0902-4441
- Publication type
Article
- DOI
10.1111/ejh.12891