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- Title
IMMUNOHISTOCHEMISTRY METHOD PRECEDED BY TISSUE TRANSFER - A RELIABLE ALTERNATIVE TO CURRENT PRACTICE OF PROSTATE PATHOLOGY.
- Authors
Anderco, Denisa; Lazar, Elena; Borda, Angela; Taban, Sorina; Mic, Felix; Loghin, Andrada; Dema, Alis
- Abstract
In the context of increased incidence of the prostate cancer, the pathologists are more frequently faced with the task to establish a diagnosis on quantitatively reduced biopsy specimens. Sometimes the usual diagnostic methods do not allow a definite morphological diagnosis due to the limited nature of suspicious lesions and inability to evaluate its architecture. In addition, the loss of these atypical foci from the paraffin blocks during repeated sections is not an isolated phenomenon. In this regard, we reassessed the cases with equivocal diagnoses established on prostate biopsy specimens in our hospital over the past 2 years. We performed the tissue transfer on charged slides, followed by AMACR/p63 cocktail immunostaining in order to establish a certain diagnosis. Following this procedure we established a final diagnosis in 17 of the 19 cases (89.47%). We claim that this method is a reliable alternative to the classical processing of minute atypical glandular lesions, when minimum two H&E-stained sections that harbour suspicious foci are available.
- Subjects
DIAGNOSIS; PROSTATE cancer; BIOPSY; PROSTATE-specific antigen; BASAL cell carcinoma; IMMUNOHISTOCHEMISTRY
- Publication
Studia Universitatis Vasile Goldis Seria Stiintele Vietii (Life Sciences Series), 2010, Vol 20, Issue 2, p11
- ISSN
1584-2363
- Publication type
Article