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- Title
Targeting DNA repair and the cell cycle in glioblastoma.
- Authors
Alexander, Brian; Pinnell, Nancy; Wen, Patrick; D'Andrea, Alan
- Abstract
Glioblastoma is a disease with poor outcomes despite standard therapy. Specific targeting of the DNA damage response is a strategy that is becoming increasingly employed in oncology and has intriguing potential for improving outcomes in glioblastoma. DNA damage targeting has implications for improving current therapy as well as the potential to leverage inherent differences in glioblastoma cells to widen the therapeutic window.
- Subjects
DNA repair; DNA damage; CELL cycle; GLIOBLASTOMA multiforme; HEALTH outcome assessment; TARGETED drug delivery
- Publication
Journal of Neuro-Oncology, 2012, Vol 107, Issue 3, p463
- ISSN
0167-594X
- Publication type
Article
- DOI
10.1007/s11060-011-0765-4