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- Title
P223 - COMPARISON OF THE RESULTS OF TWO DIFFERENT INSTRUMENTS IN THERAPEUTIC DRUG MONITORING.
- Authors
ÖZTAŞ, YEŞİM; EL MOUSTAFA, KHALED; İŞERİ, SEVGİN ÖZLEM; DİKMEN, Z. GÜNNUR; PINAR, ASLI; AKBIYIK, FİLİZ
- Abstract
Therapeutic drug monitoring is one of the most important responsibilities of biochemistry laboratory. The clinician optimizes the dosage, evaluates the toxicity and clinical efficiency according to the measured drug level. In this study serum levels of Digoxin, Phenytoin, Phenobarbital and Carbamazepine were measured by MGC 240 and Advia 1800.instruments. Digoxin levels were measured in 44, Phenytoin levels were measured in 53, Phenobarbital levels were measured in 17 and Carbamazepine levels were measured in 34 paients. Phenytoin, Phenobarbital and Carbamazepine levels were measured by cloned enzyme donor immunoassay (CEDIA) technique and Digoxin levels were measured by homogeneous immunoassay technique by Microgenics kits in MGC 240 instrument. In Advia 1800 instrument Phenytoin and Carbamazepine levels were measured by enzyme multiplying immunoassay (EMIT) technique, Digoxin levels were measured by latex enhanced immunoturbidimetric assay and Phenobarbital levels were measured by homogenous immunoassay kits of Advia Chemistry Systems. Digoxin levels were 0.02-2.9 ng/mL and 0-2.6 ng/mL, Phenytoin levels were 1.0-37.5 µg/ mL and 1.7-41.6 µg/mL, Phenobarbital levels were 4.9-40.3 µg/mL and 7.0-39.0 µg/mL, and Carbamazepine levels were 2.8-14.0 µg/mL and 3.4-15.5 µg/mL in MGC 240 and Advia 1800 instruments respectively. Each drug levels measured by two instruments were plotted and the R2 values were calculated as 0.95, 0.98, 0.95 and 0.96 for Digoxin, Phenytoin, Phenobarbital and Carbamazepine respectively. High correlation was found between the drug levels measured and it is concluded that the results were compatable in two different instruments.
- Subjects
DRUG monitoring research; DRUG analysis; BIOCHEMISTRY; BIOLOGY; LABORATORIES
- Publication
Turkish Journal of Biochemistry / Turk Biyokimya Dergisi, 2012, Vol 37, Issue S1, p364
- ISSN
0250-4685
- Publication type
Article