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- Title
P087 - THE EFFECT OF ENDOTHELIAL DYSFUNCTION BIOCHEMICAL MARKERS AND FLOW-MEDIATED DILATION ON THE PREDICTIVITY OF EXERCISE ECG.
- Authors
TOPRAK, Muhammet Sait; SÖNMEZ, Hüseyin; ÖZTÜRK, Zeynep; EKMEKÇİ, Hakan; EKMEKÇİ, Özlem BALCI; ÇAKMAK, Hüseyin Altuğ; İKİTİMUR, Barış; KARADAĞ, Bilgehan; İLERİGELEN, Barış
- Abstract
Endothelial dysfunction is occurred in early atherosclerosis and induced by imbalance between endothelium-derived vasodilator and vasoconstrictor activity. Various oxidative stress molecules and inflammation have a significant role in the development of endothelial dysfunction. These inflammatory markers include Lipoprotein-associated phospholipase A2 (Lp-PLA2) for vascular inflammation and an acute phase reactant High-Sensitive C-Reactive Protein (hs-CRP). Oxidized-LDL, Nitric oxide (NO) and Sialic acid molecules play a role in endothelial dysfunction through several oxidative mechanisms. We have included 30 patients with negative Exercise ECG test and 30 patients with positive Exercise ECG test in our study. The aim of our study, was to clarify \"possible biochemical markers of endothelial dysfunction and flow-mediated dilation (FMD) findings could increase predictivity of Exercise ECG test.\" In our study, due to a lower results for biochemical parameters of endothelial dysfunction and FMD rates in patients with Exercise ECG (+), further, we divided the patients into three groups as high risk (1st group), less risk (2nd group) and the lowest risk (3rd group) for FMD rates. Lp-PLA2 activity, total and LDL-cholesterol, triglyceride and hs-CRP levels were insignificantly higher for 1st group when compared to other groups. We observed no change for HDL-cholesterol, Oxidized-LDL, NO and Sialic Acid levels across the risk groups. As a result, we could say biochemical markers of endothelial dysfunction and FMD rates does not support the findings of the Exercise ECG sufficiently, and wide range studies will be required in the assessment of Lp-PLA2 or hs-CRP as a predictor of endothelial dysfunction.
- Subjects
BIOMARKERS; ENDOTHELIUM; ATHEROSCLEROSIS
- Publication
Turkish Journal of Biochemistry / Turk Biyokimya Dergisi, 2012, Vol 37, Issue S1, p228
- ISSN
0250-4685
- Publication type
Abstract