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- Title
The Reduced Predictive Value of Interleukin 28b Gene Polymorphisms in a Cohort of Patients With Thyroiditis Developed During Antiviral Therapy For Chronic Hepatitis C: A Preliminary Study.
- Authors
Tran, Huy A.; Jones, Tracey L.; Ianna, Elizabeth A.; Gibson, Robert A.; Reeves, Glenn E. M.
- Abstract
Background: Single nucleotide polymorphism in the interleukin28B (IL28B) gene was recently shown to be associated with a significant increase in response to interferon-α and ribavirin treatment in patients with chronic hepatitis C. Similarly, thyroid disease (TD) occurring during treatment confer an improved sustained virologic response (SVR). Objectives: To determine the role of IL28B genotypes in a cohort of hepatitis C patients who develop TD during treatment and its relationship to SVR. Patients and Methods: IL28B gene profiles including rs12979860, rs12980275 and rs 8099917 and their genotypes were determined in a cohort of 23 hepatitis C patients who developed TD during treatment and their relationship to SVR. Results: Out of 23 studies cases, 19 has one or more favorable genotypes, of which 15 (78.9 %) achieved SVR. Eleven has all three unfavorable genotypes and yet achieved 72.7 % SVR. The presence of more than one favorable genotype only correctly predicts SVR vs. non-SVR in ~50 %of cases, i.e. by chance. Conclusions: Despite the small number of subjects, the presence of one or more unfavorable IL28B genotype does not portend a poor SVR prognostic outcome. This suggests that TD in this clinical context may be a critical factor in the achievement of SVR, probably above that of the genetic predisposition.
- Subjects
ANTIVIRAL agents; CHI-squared test; CONFIDENCE intervals; FISHER exact test; GENES; GENETIC polymorphisms; HEPATITIS C; INTERLEUKINS; MULTIVARIATE analysis; REGRESSION analysis; T-test (Statistics); THYROIDITIS; THYROTROPIN; U-statistics; PREDICTIVE tests; DESCRIPTIVE statistics
- Publication
Hepatitis Monthly, 2012, Vol 12, Issue 8, p1
- ISSN
1735-143X
- Publication type
Article
- DOI
10.5812/hepatmon.6036