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- Title
Clinical Characteristics of Non-Immune-Mediated, Idiopathic Type 1 (Type IB) Diabetes Mellitus in Japanese Children and Adolescents.
- Authors
Urakami, T.; Inami, I.; Morimoto, S.; Kubota, S.; Owada, M.
- Abstract
To clarify the characteristics of idiopathic type 1 (type IB) diabetes mellitus (DM), we compared the clinical features of immunemediated type 1 (type 1A) DM and type IB DM in 85 Japanese children and adolescents with DM. The prevalence of type IB DM was 16.5%. The patients with type IB DM were significantly younger at diagnosis and had a higher frequency of preceding viral infection before onset, compared to those with type 1A DM. They displayed more severe metabolic decompensation with a higher frequency of ketoacidosis at diagnosis than patients with type 1A DM. They had strong, HLA-defined genetic susceptibility, similar to that in type 1A DM. Some patients with type IB DM exhibited a remarkably abrupt onset and rapid loss of β-cell capacity. From these findings, it is considered that type IB DM differs from type 1A DM with respect to age at onset and the trigger event, such as viral infection, leading to rapid destruction of β-cells without autoimmunity in the etiology of the disease.
- Publication
Journal of Pediatric Endocrinology & Metabolism, 2002, Vol 15, Issue 3, p283
- ISSN
0334-018X
- Publication type
Article
- DOI
10.1515/jpem.2002.15.3.283