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- Title
Diagnostic Assessment in Primary Progressive Aphasia: An Illustrative Case Example.
- Authors
Europa, Eduardo; Iaccarino, Leonardo; Perry, David C.; Weis, Elizabeth; Welch, Ariane E.; Rabinovici, Gil D.; Miller, Bruce L.; Gorno-Tempini, Maria Luisa; Henry, Maya L.
- Abstract
Purpose: Diagnosis and classification of primary progressive aphasia (PPA) requires confirmation of specific speech and language symptoms, highlighting the important role of speech-language pathologists in the evaluation process. The purpose of this case report is to inform speech-language pathologists regarding current practices for diagnostic assessment in PPA, describing standard approaches as well as complementary, state-of-the-art procedures that may improve diagnostic precision. Method: We describe the diagnostic evaluation of a 49-year-old woman with complaints of progressive word-finding difficulty. She completed standard neurological, neuropsychological, and speech-language evaluations, as well as magnetic resonance and positron emission tomography imaging of her brain. In addition, a history of developmental speech, language, and learning abilities was obtained, as well as genetic testing and assessment of cerebrospinal fluid biomarkers. We discuss the evaluation results in the context of the most current research related to PPA diagnosis. Conclusion:Detailed behavioral assessment, thorough intake of symptom history and neuro developmental differences, multimodal neuroimaging, and comprehensive examination of genes and biomarkers are of paramount importance for detecting and characterizing PPA, with ramifications for early behavioral and/or pharmacological intervention.
- Subjects
DIAGNOSIS of aphasia; BIOMARKERS; BRAIN; CEREBROSPINAL fluid; DECISION making; DIAGNOSIS; MAGNETIC resonance imaging; NEUROPSYCHOLOGICAL tests; MEDICAL needs assessment; MEDICAL history taking; RESEARCH funding; DECISION making in clinical medicine; GENETIC testing
- Publication
American Journal of Speech-Language Pathology, 2020, Vol 29, Issue 4, p1833
- ISSN
1058-0360
- Publication type
Article
- DOI
10.1044/2020_AJSLP-20-00007