We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Cytologic, histologic, and immunohistochemical features of lingual liposarcoma in a dog.
- Authors
Piseddu, Eleonora; De Lorenzi, Davide; Freeman, Kathleen; Masserdotti, Carlo
- Abstract
A 9-year-old female spayed mixed-breed dog was presented to the referring veterinarian with a history of decreased appetite and difficulty with prehension and swallowing because of a firm oval mass in the tongue. On cytologic evaluation of a fine-needle aspirate of the mass there were numerous round to polygonal cells organized individually or in loose clusters with rare branching capillaries. The cells had eosinophilic granular cytoplasm, round to oval nuclei, and occasionally indistinct borders. The cytologic diagnosis was granular cell tumor (GCT) of the tongue. Impression smears of a biopsy sample of the lingual mass contained similar eosinophilic granular cells with variable numbers of clear vacuoles in the background, numerous perivascular arrangements, and occasional lipoblasts, suggestive of liposarcoma. On histologic examination the tumor was composed of numerous lipocytes with rare foci of round eosinophilic granular cells without evidence of vacuolation; occasionally, atypical mitotic figures were seen. Immunohistochemically, the cells were uniformly negative for periodic acid-Schiff and did not express smooth muscle actin, desmin, or cytokeratin but were immunoreactive for vimentin and S100. A diagnosis of well-differentiated liposarcoma was made on the basis of morphologic and immunohistochemical results. Eosinophilic granular cells may be a component of well-differentiated liposarcoma and are not limited to GCT. Liposarcoma should be considered in the differential diagnoses of lingual tumors in the dog when cytological evaluation reveals eosinophilic granular cells consistent with GCT.
- Subjects
CASE studies; DOG diseases; LIPOSARCOMA; EOSINOPHILIC granuloma; VETERINARY cytodiagnosis; MESENCHYMAL stem cells; DIAGNOSIS
- Publication
Veterinary Clinical Pathology, 2011, Vol 40, Issue 3, p393
- ISSN
0275-6382
- Publication type
Article
- DOI
10.1111/j.1939-165X.2011.00342.x