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- Title
Gene expression in the in vitro-produced preimplantation bovine embryos.
- Authors
H. Badr; G. Bongioni; A.S.S. Abdoon; O. Kandil; R. Puglisi
- Abstract
SummaryRecent studies have demonstrated the relevance of a gene expression profile as a clinically important key feature determining embryo quality during the in vitropreimplantation period. Although the oocyte origin can play a crucial role in blastocyst yield, the postfertilization culture period has a profound effect in determining the blastocyst quality with particular regard to the relative abundance of many developmentally and clinically important candidate genes. During the preimplantation period, the embryo undergoes several morphogenetic developmental events including oocyte maturation, minor and major forms of embryonic genome activation and transition of transcription from maternal to embryonic control. The effect of an altered gene expression pattern on the in vitro-produced bovine embryos, particularly when cultured under suboptimal conditions, was reflected by the occurrence of clinically important phenomena like apoptosis and the large offspring syndrome. This review attempts to focus on the morphogenetic embryo development and gene expression profile in the in vitro-produced bovine embryos, with special emphasis on the different parameters that may alter gene expression pattern during the critical period of in vitroculture. The effect of the in vitrosystem, as reflected by some clinically important phenomena like apoptosis, is also discussed.
- Subjects
GENE expression; FERTILIZATION in vitro; BLASTOCYST; APOPTOSIS; EMBRYOLOGY
- Publication
Zygote, 2007, Vol 15, Issue 4, p355
- ISSN
0967-1994
- Publication type
Article
- DOI
10.1017/S0967199407004315