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- Title
Skuteczność i bezpieczeństwo etabonianu loteprednolu w leczeniu chorób zapalnych oczu.
- Authors
Łazicka-Gałecka, Monika; Gałecki, Tomasz; Szaflik, Jacek P.
- Abstract
Topical corticosteroid drops are routinely used after cataract surgery, glaucoma surgery, keratoplasty and in treatment of ocular inflammatory diseases. By inhibiting the activation of phospholipase A2, corticosteroids prevent arachidonic acid formation like prostaglandins, prostacyclin and leukotrienes. Compared with dexamethasone, their binding affinity to a glucocorticoid receptor was 4.3 times higher. Long term use of topical steroids is likely to induce adverse effects, such as elevated intraocular pressure, which can lead to glaucoma. Loteprednol etabonate is rapidly metabolized by tissue esterases, limiting its concentration in ciliary body and thus reducing the risk of adverse effects. Due to its chemical structure, loteprednol etabonate does not form covalent bonds with crystalline lens proteins, which prevents cataract formation. Loteprednol etabonate is a very potent anti-inflammatory agent and its administration is associated with a decreased risk of side effects.
- Publication
Acta Ophthalmologica Polonica / Klinika Oczna, 2017, Vol 119, Issue 4, p239
- ISSN
0023-2157
- Publication type
Article