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- Title
Plasma oxidative parameters and mortality in patients with severe burn injury.
- Authors
Ritter, Cristiane; Andrades, Michael; Guerreiro, Márcio; Zavaschi, Leonardo; Gelain, Daniel Pens; Souza, Luis Fernando; Ribeiro, Cyntia A.; Clausell, Nadine; Menna-Barreto, Sérgio; Moreira, José Cláudio F.; Dal-Pizzol, Felipe; Guerreiro, Márcio; Menna-Barreto, Sérgio; Moreira, José Cláudio F
- Abstract
<bold>Objective: </bold>To determine xanthine oxidase and superoxide dismutase activities, lipid peroxidation, protein carbonylation, and total radical-trapping antioxidant parameter in survivors and nonsurvivors patients with severe burn injury.<bold>Design and Setting: </bold>Prospective, comparative observational study in an intensive care unit, burn division, in a trauma hospital.<bold>Patients: </bold>Twenty-five consecutive patients who met the established criteria for severe burn injury (total burn surface area of more than 30%).<bold>Measurements and Results: </bold>Plasma thiobarbituric acid reactive species and protein carbonyls levels were significantly higher in nonsurvivors than in survivors at 0 and 6 h. Elevated xanthine oxidase activity at 0 h was associated with adverse outcome after burn injury. In contrast, plasma superoxide dismutase activity and total radical-trapping antioxidant parameter did not differ significantly between nonsurvivors and survivors at any time point.<bold>Conclusions: </bold>For the first time we demonstrate the value of oxidative parameters, namely thiobarbituric acid reactive species, protein carbonyls, and xanthine oxidase activity, in identifying burn patients with a poor prognosis. Whether these parameters are merely markers of clinical course, or whether they signal specific deleterious effects of oxidative stress during the burn injury remains to be elucidated.
- Subjects
XANTHINE oxidase; OXIDASES; INTENSIVE care units; OXIDATIVE stress; DIAGNOSIS; OXIDATION-reduction reaction; BARBITURATES; BLOOD proteins; BURNS &; scalds; COMPARATIVE studies; CRITICAL care medicine; LONGITUDINAL method; RESEARCH methodology; MEDICAL cooperation; LIPID peroxidation (Biology); OXIDOREDUCTASES; PROGNOSIS; RESEARCH; SUPEROXIDE dismutase; EVALUATION research
- Publication
Intensive Care Medicine, 2003, Vol 29, Issue 8, p1380
- ISSN
0342-4642
- Publication type
journal article
- DOI
10.1007/s00134-003-1833-9