We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A Survey of Correlation Between Insulin-Like Growth Factor-I (IGF-I) Levels and Severity of Liver Cirrhosis.
- Authors
Khoshnood, Asghar; Toosi, Mohsen Nasiri; Faravash, Mohammad Jafar; Esteghamati, Alireza; Froutan, Hosein; Ghofrani, Hadi; Kalani, Mohammad; Miroliaee, Arash; Abdollahi, Ahmad; Yasir, Andrabi
- Abstract
Background: Insulin-like growth factor is a polypeptide with endocrine, autocrine and paracrine effects which its structure is similar to the insulin molecule. While various tissues secrete IGF-1, 90% of the circulating IGF-1 is secreted by liver. Cirrhosis of liver is a condition accompanied by decreased level of IGF-1, in which the level of IGF-1 may be further decreased thorough the progression of the disease. Objectives: The aim of the present study was to demonstrate the relation between the IGF-1 levels and severity of liver disease according to Child- Pugh and Model for end stage liver diseases (MELD) Scores. Patients and Method: This was a descriptive-analytic cross sectional study performed on patients with cirrhosis admitted to gastroenterology clinic of Imam Khomeini Hospital in Tehran, Iran during the years 2007-2008. The diagnosis was based on liver biopsy. Initially for all patients, laboratory investigations including IGF-1, CBC, liver Enzymes, Alkaline phosphates, serum Albumin, Creatinine, direct and total Bilirubin were conducted. Also ultrasound and endoscopy were performed for evaluation of ascites and varices. Results: 100 patients with cirrhosis with a male to Female ratio of 63:37 and a mean age of 44.4 ± 15 years were enrolled in the study. Median IGF-1 was 92.95 ± 91.51 ng/mL. 14 patients (14%) had IGF-1 within normal limits while 86 patients (86%) had abnormal IGF-1 levels. In all patients the correlation coefficient between IGF-1 and MELD was -0.317 (P = 0.001) and 0.478 between IGF-1 and Child- Pugh (P < 0.001). Conclusions: Our findings showed that IGF-1 can be used as an index for evaluating the severity of cirrhosis; also it can be used for determining the severity of the disease, when liver biopsy is not possible.
- Subjects
IRAN; CIRRHOSIS of the liver; ACADEMIC medical centers; BIOPSY; BLOOD testing; ENDOSCOPY; SURVEYS; ULTRASONIC imaging; SEVERITY of illness index; CONNECTIVE tissue growth factor; DATA analysis software; DESCRIPTIVE statistics; PROGNOSIS
- Publication
Hepatitis Monthly, 2013, Vol 13, Issue 2, p1
- ISSN
1735-143X
- Publication type
Article
- DOI
10.5812/hepatmon.6181