We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Booster Vaccination Against SARS-CoV-2 Induces Potent Immune Responses in People With Human Immunodeficiency Virus.
- Authors
Fidler, Sarah; Fox, Julie; Tipoe, Timothy; Longet, Stephanie; Tipton, Tom; Abeywickrema, Movin; Adele, Sandra; Alagaratnam, Jasmini; Ali, Mohammad; Aley, Parvinder K; Aslam, Suhail; Balasubramanian, Anbhu; Bara, Anna; Bawa, Tanveer; Brown, Anthony; Brown, Helen; Cappuccini, Federica; Davies, Sophie; Fowler, Jamie; Godfrey, Leila
- Abstract
Background People with human immunodeficiency virus (HIV) on antiretroviral therapy (ART) with good CD4 T-cell counts make effective immune responses following vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). There are few data on longer term responses and the impact of a booster dose. Methods Adults with HIV were enrolled into a single arm open label study. Two doses of ChAdOx1 nCoV-19 were followed 12 months later by a third heterologous vaccine dose. Participants had undetectable viraemia on ART and CD4 counts >350 cells/µL. Immune responses to the ancestral strain and variants of concern were measured by anti-spike immunoglobulin G (IgG) enzyme-linked immunosorbent assay (ELISA), MesoScale Discovery (MSD) anti-spike platform, ACE-2 inhibition, activation induced marker (AIM) assay, and T-cell proliferation. Findings In total, 54 participants received 2 doses of ChAdOx1 nCoV-19. 43 received a third dose (42 with BNT162b2; 1 with mRNA-1273) 1 year after the first dose. After the third dose, total anti-SARS-CoV-2 spike IgG titers (MSD), ACE-2 inhibition, and IgG ELISA results were significantly higher compared to Day 182 titers (P <.0001 for all 3). SARS-CoV-2 specific CD4+ T-cell responses measured by AIM against SARS-CoV-2 S1 and S2 peptide pools were significantly increased after a third vaccine compared to 6 months after a first dose, with significant increases in proliferative CD4+ and CD8+ T-cell responses to SARS-CoV-2 S1 and S2 after boosting. Responses to Alpha, Beta, Gamma, and Delta variants were boosted, although to a lesser extent for Omicron. Conclusions In PWH receiving a third vaccine dose, there were significant increases in B- and T-cell immunity, including to known variants of concern (VOCs).
- Subjects
HIV infections; HIV-positive persons; KRUSKAL-Wallis Test; COVID-19; IMMUNIZATION; SARS-CoV-2; COVID-19 vaccines; QUANTITATIVE research; MANN Whitney U Test; HIGHLY active antiretroviral therapy; QUALITATIVE research; ENZYME-linked immunosorbent assay; DESCRIPTIVE statistics; DATA analysis software
- Publication
Clinical Infectious Diseases, 2023, Vol 76, Issue 2, p201
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1093/cid/ciac796