We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Serum HBsAg levels during peginterferon α-2a treatment with or without thymosin α-1 in HBeAg-positive chronic hepatitis B patients.
- Authors
Song, Eun Young; Shin, Yunsu; Roh, Eun Youn; Sue, Shin; Park, Myoung Hee; Kim, Bo Hyun; Kim, Won; Yoon, Jung-Hwan; Lee, Youn-Jae; Park, Sung Jae; Jung, Eun Uk; Lee, Jeong-Hoon; Myung, Sun Jung; Kim, Yoon-Jun; Lee, Hyo-Suk
- Abstract
The importance of serum hepatitis B surface antigen (HBsAg) level as a surrogate marker for viral load and a predictor of treatment response remains unclear. The aim of this study was to investigate whether serum HBsAg correlates with serum hepatitis B virus (HBV) DNA during peginterferon (PEG-IFN) α-2a treatment (with or without thymosin α-1) in hepatitis B e antigen (HBeAg)-positive chronic hepatitis B patients and whether it can predict treatment response. Sera from 37 HBeAg-positive chronic hepatitis B patients receiving 48-weeks PEG-IFN α-2a with (n = 20) or without (n = 17) an initial 12-weeks thymosin α-1 were obtained at baseline and at weeks 12, 24, 36, 48 (end of treatment), 56, 72, 84, and 96 (end of follow-up). Taqman HBV DNA tests (Roche) and Architect HBsAg QT (Abbott) were performed. There was a moderate correlation between the HBsAg and HBV DNA levels (r = 0.452, P < 0.001). Median HBsAg levels at baseline and at week 96 were 6,218 IU/ml and 4,038 IU/ml, respectively. The mean HBV DNA and alanine aminotransferase (ALT) levels were 7.48 log10 IU/ml and 173 IU/L at baseline and 5.37 log10 IU/ml and 102 IU/L at week 96, respectively. A decrease to <60% of baseline levels of HBsAg at week 12 was identified as an independent predictive factor for HBeAg seroconversion (OR = 45.7, P < 0.05) at week 96. Serum HBsAg levels may be helpful for predicting the response to PEG-IFN therapy in HBeAg-positive chronic hepatitis B patients. J. Med. Virol. 83:88-94, 2011. © 2010 Wiley-Liss, Inc.
- Publication
Journal of Medical Virology, 2011, Vol 83, Issue 1, p88
- ISSN
0146-6615
- Publication type
Article
- DOI
10.1002/jmv.21961