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- Title
The p38 and Hog1 SAPKs control cell cycle progression in response to environmental stresses
- Authors
Duch, Alba; de Nadal, Eulàlia; Posas, Francesc
- Abstract
Abstract: In response to environmental stresses, cells need to activate an adaptive program to maximize cell progression and survival. Stress-activated protein kinases (SAPK) are key signal transduction kinases required to respond to stress. Prototypical members of SAPKs are the yeast Hog1 and mammalian p38. Upon stress, those enzymes play a critical role in mounting the adaptive responses to stress such as the regulation of metabolism and the control of gene expression. In addition, a major function of SAPKs in response to stress is to modulate cell cycle progression. In this review, we focus on the role of Hog1 and p38 in the control of cell cycle progression in response to environmental stresses.
- Subjects
CELL cycle; ENVIRONMENTAL engineering; METABOLIC regulation; GENE expression; MITOGEN-activated protein kinases; CELLULAR signal transduction; PROTOTYPES
- Publication
FEBS Letters, 2012, Vol 586, Issue 18, p2925
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2012.07.034