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- Title
Protozoan genomics for drug discovery.
- Authors
Chaudhary, Kshitiz; Roos, David S.
- Abstract
The article focuses on the utilization of protozoan genomics for development of new drugs. Of the ten diseases targeted as research priorities by the World Health Organization's Special Program for Research and Training in Tropical Diseases, one is caused by a virus, two by bacterial pathogens, three by helminth parasites and four by protozoan parasites. The development of drugs, vaccines and diagnostics can be pursued from an evolutionary perspective, taking advantage of comparative genomics to identify and exploit characteristics that distinguish pathogen and host. Genome sequences are being deciphered at an ever-increasing rate, with each new entry providing numerous opportunities for comparison with those already available.
- Subjects
GENOMICS; DRUG development; MOLECULAR genetics; PARASITES; GENETIC research; PATHOGENIC microorganisms
- Publication
Nature Biotechnology, 2005, Vol 23, Issue 9, p1089
- ISSN
1087-0156
- Publication type
Article
- DOI
10.1038/nbt0905-1089