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- Title
Serum proteomics profiling-a young technology begins to mature.
- Authors
Coombes, Kevin R; Morris, Jeffrey S; Hu, Jianhua; Edmonson, Sarah R; Baggerly, Keith A
- Abstract
The article presents information on serum proteomics profiling a young technology that began to mature with time. During the three years since the U.S. National Cancer Institute-Food and Drug Administration (NCI-FDA) proteomics group published their seminal but flawed study using mass spectrometry to profile the serum proteome of ovarian cancer patients, more than 60 published studies have applied similar technology to a wide range of cancers and other diseases. It is important to recognize the provisional nature of the conclusions of most serum proteomic studies carried out to date. In most cases where the protein peaks have been identified, they have turned out to be well-known, acute-phase proteins.
- Subjects
UNITED States; NATIONAL Cancer Institute (U.S.); PROTEOMICS; BLOOD plasma; MOLECULAR biology; MASS spectrometry
- Publication
Nature Biotechnology, 2005, Vol 23, Issue 3, p291
- ISSN
1087-0156
- Publication type
Editorial
- DOI
10.1038/nbt0305-291