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- Title
Treatment outcomes with whole‐field versus split‐field intensity‐modulated radiotherapy for patients with nasopharyngeal carcinoma.
- Authors
Lin, Chun‐Shu; Chen, Yuan‐Wu; Liu, Shao‐Cheng; Tsao, Chih‐Cheng; Lin, Kuen‐Tze; Lee, Steve P.; Fan, Chao‐Yueh; Liu, Ming‐Yueh; Shen, Po‐Chien; Jen, Yee‐Min
- Abstract
Background: The purpose of this study was to present our comparison of the clinical outcome of patients with nasopharyngeal carcinoma (NPC) treated with whole‐field intensity‐modulated radiotherapy (whole‐field‐IMRT) or split‐field‐IMRT. Methods: We retrospectively studied 388 patients with M0 NPC. The median lower neck doses were 50 Gy in 1.35 Gy/fractions for the 240 whole‐field‐IMRT patients, and 50.4 Gy in 1.8 to 2.0 Gy/fractions for the 148 split‐field‐IMRT patients. Results: The IMRT technique did not affect the overall survival (OS; P =.077) and locoregional control (P =.231) rates. However, the split‐field‐IMRT group had more locoregional recurrences at the whole neck (P =.005) but not at the nasopharynx (P =.968) or the lower neck (P =.485). The patients treated with split‐field‐IMRT (43.2%) had more grade III neck fibrosis than the patients who received whole‐field‐IMRT (18.3%; P <.001). Only 1 patient had temporal lobe necrosis in our study. Conclusion: Our study shows that whole‐field‐IMRT using a lower dose/fraction for the lower neck results in at least comparable locoregional control and less fibrosis compared to conventional fraction with split‐field‐IMRT.
- Subjects
INTENSITY modulated radiotherapy; TREATMENT effectiveness
- Publication
Head & Neck, 2019, Vol 41, Issue 3, p598
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.25328