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- Title
Functions and pathologies of BiP and its interaction partners.
- Authors
Dudek, J.; Benedix, J.; Cappel, S.; Greiner, M.; Jalal, C.; Müller, L.; Zimmermann, R.
- Abstract
The endoplasmic reticulum (ER) is involved in a variety of essential and interconnected processes in human cells, including protein biogenesis, signal transduction, and calcium homeostasis. The central player in all these processes is the ER-lumenal polypeptide chain binding protein BiP that acts as a molecular chaperone. BiP belongs to the heat shock protein 70 (Hsp70) family and crucially depends on a number of interaction partners, including co-chaperones, nucleotide exchange factors, and signaling molecules. In the course of the last five years, several diseases have been linked to BiP and its interaction partners, such as a group of infectious diseases that are caused by Shigella toxin producing E. coli. Furthermore, the inherited diseases Marinesco-Sjögren syndrome, autosomal dominant polycystic liver disease, Wolcott-Rallison syndrome, and several cancer types can be considered BiP-related diseases. This review summarizes the physiological and pathophysiological characteristics of BiP and its interaction partners.
- Subjects
ENDOPLASMIC reticulum; NUCLEOTIDES; POLYPEPTIDES; CARRIER proteins; HUMAN chromosome abnormalities; LIVER diseases; GENETICS
- Publication
Cellular & Molecular Life Sciences, 2009, Vol 66, Issue 9, p1556
- ISSN
1420-682X
- Publication type
Article
- DOI
10.1007/s00018-009-8745-y