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- Title
An Observational Prospective Cohort Study of Vaccine Effectiveness Against Severe Acute Respiratory Syndrome Coronavirus 2 Infection of an Aerosolized, Inhaled Adenovirus Type 5–Vectored Coronavirus Disease 2019 Vaccine Given as a Second Booster Dose in Guangzhou City, China
- Authors
Wang, Fu-Zhen; Zhang, Chun-Huan; Tang, Lin; Rodewald, Lance E; Wang, Wen; Liu, Si-Yu; Wang, Wen-Ji; Wu, Dan; Liu, Qian-Qian; Wang, Xiao-Qi; Huang, Li-Fang; Huang, Ao-Di; Bao, Li-Ming; Zhang, Zhou-Bin; Yin, Zun-Dong
- Abstract
Using a prospective, observational cohort study during the post–"dynamic COVID-zero" wave in China, we estimated short-term relative effectiveness against Omicron BA.5 infection of inhaled aerosolized adenovirus type 5–vectored ancestral strain coronavirus disease 2019 (COVID-19) vaccine as a second booster dose approximately 1 year after homologous boosted primary series of inactivated COVID-19 vaccine compared with no second booster. Participants reported nucleic acid or antigen test results weekly until they tested positive or completed predesignated follow-up. After excluding participants infected <14 days after study entry, relative effectiveness among the 6576 participants was 61% in 18- to 59-year-olds and 38% in ≥60-year-olds and was sustained for 12 weeks.
- Subjects
CHINA; GUANGZHOU (China); COVID-19; ADENOVIRUS diseases; BOOSTER vaccines; VACCINE effectiveness
- Publication
Journal of Infectious Diseases, 2024, Vol 229, Issue 1, p117
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1093/infdis/jiad338