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- Title
Serologic Response to Human Papillomavirus Genotypes Among Unvaccinated Women: Findings From the HITCH Cohort Study.
- Authors
Morais, Samantha; Wissing, Michel D; Khosrow-Khavar, Farzin; Burchell, Ann N; Tellier, Pierre-Paul; Coutlée, François; Waterboer, Tim; El-Zein, Mariam; Franco, Eduardo L
- Abstract
Background Humoral immune responses may be critical for preventing, controlling, and/or eliminating human papillomavirus (HPV) infection. We analyzed humoral response to natural HPV infection considering phylogenetic relatedness among unvaccinated women. Methods We included 399 young women attending university/college in Montreal, Canada who were participants of the HITCH cohort. Participants provided blood samples at baseline and 5 follow-up visits. Antibody response to bacterially expressed L1 and E6 glutathione S-transferase (GST) fusion proteins, and virus-like particles (VLP-L1) of Alphapapillomavirus types were measured using multiplex serology. We assessed correlations and associations between HPV types at baseline using Pearson correlation coefficients (r) and univariable linear regressions. Results At baseline, > 40% were seropositive for GST-L1 antibodies of at least 1 HPV type. Strong correlations between GST-L1 were observed for α9 HPV types: 58–52 (r = 0.86), 58–33 (r = 0.75), 33–52 (r = 0.72), and between GST-E6: 52–11 (r = 0.84), 52–18 (r = 0.79), 58–33 (r = 0.78), 35–11 (r = 0.76). HPV16 VLP-L1 moderately explained variability in HPV16 GST-L1 (regression coefficient [b] = 0.38, R 2 = 43.1%), and HPV45 GST-L1 in HPV18 GST-L1 (b = 0.68, R 2 = 42.8%). GST-E6 antibodies accounted for a low to moderate proportion of variability in HPV16 and HPV18 GST-E6 (R 2 = 6.4%–62.2%). Conclusions Associations between naturally induced HPV-specific antibodies depend on phylogenetic relatedness.
- Subjects
MONTREAL (Quebec); HUMAN papillomavirus; VACCINATION status; VACCINATION; CHIMERIC proteins; HUMORAL immunity
- Publication
Journal of Infectious Diseases, 2023, Vol 227, Issue 10, p1173
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1093/infdis/jiac437