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- Title
Bacterial Communities Associated With Abnormal Nugent Score in Postmenopausal Versus Premenopausal Women.
- Authors
Mitchell, Caroline M; Srinivasan, Sujatha; Ma, Nanxun; Reed, Susan D; Wu, Michael C; Hoffman, Noah G; Valint, Daniel J; Proll, Sean; Fiedler, Tina L; Agnew, Kathy J; Guthrie, Katherine A; Fredricks, David N
- Abstract
The Nugent score is the reference standard for bacterial vaginosis (BV) diagnosis but has not been validated in postmenopausal women. We compared relative abundances from 16S ribosomal RNA gene sequencing of vaginal microbiota with Nugent score in cohorts of premenopausal (n = 220) and postmenopausal (n = 144) women. In premenopausal women, 33 taxa were significantly correlated with Nugent score, including the classic BV-associated taxa Gardnerella, Atopobium, Sneathia, Megasphaera, and Prevotella. In postmenopausal women, 11 taxa were significantly associated with Nugent score, including Prevotella but no other BV-associated genera. High Nugent scores should not be used to infer BV in postmenopausal women.
- Subjects
BACTERIAL communities; BACTERIAL vaginitis; POSTMENOPAUSE; RIBOSOMAL RNA; HUMAN microbiota; BACTERIA classification; BACTERIAL vaginitis diagnosis; PERIMENOPAUSE; RNA; VAGINA
- Publication
Journal of Infectious Diseases, 2021, Vol 223, Issue 12, p2048
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiaa675