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- Title
A gene variant of AKR1C3 contributes to interindividual susceptibilities to atopic dermatitis triggered by particulate air pollution.
- Authors
Vogeley, Christian; Kress, Sara; Lang, Dieter; Vogel, Christoph F. A.; Hartung, Frederick; Brenden, Heidi; Nakamura, Motoki; Grether‐Beck, Susanne; Rossi, Andrea; Krutmann, Jean; Schikowski, Tamara; Haarmann‐Stemmann, Thomas
- Abstract
Keywords: air pollution; aldo-keto reductase; atopic dermatitis; particulate matter; polycyclic aromatic hydrocarbons EN air pollution aldo-keto reductase atopic dermatitis particulate matter polycyclic aromatic hydrocarbons 1372 1375 4 05/03/23 20230501 NES 230501 The pathogenesis of atopic dermatitis (AD) involves an impairment of the skin barrier by an interplay of genetic and environmental factors. While some studies found a significant association between PM exposure and AD symptoms, in particular in children, other studies reported null associations.[[1]] This data inconsistency in airborne PM exposure-related AD may depend on interindividual genetic susceptibilities.[3] A gene that is highly expressed in lesional AD skin[4] and upregulated in PAH-exposed keratinocytes in an aryl hydrocarbon receptor-dependent manner[5] encodes aldo-keto reductase (AKR)1C3.
- Subjects
ATOPIC dermatitis; GENETIC variation; AIR pollution; FILAGGRIN; HUMAN genetic variation; SINGLE nucleotide polymorphisms; ECZEMA; MAST cell disease
- Publication
Allergy, 2023, Vol 78, Issue 5, p1372
- ISSN
0105-4538
- Publication type
Article
- DOI
10.1111/all.15622