We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Infant feeding clusters are associated with respiratory health and allergy at school age in the PARIS birth cohort.
- Authors
Amazouz, Hélène; de Lauzon‐Guillain, Blandine; Bourgoin‐Heck, Mélisande; Just, Jocelyne; Beydon, Nicole; Lezmi, Guillaume; Rancière, Fanny; Momas, Isabelle; Eiwegger, Thomas
- Abstract
Background: As infant feeding may influence allergy development, we aimed to identify groups of infants based on feeding practices and to examine their associations with respiratory health/allergy at 8 years in the PARIS birth cohort. Methods: Data on breastfeeding, consumption of infant formula (regular, pre‐/probiotics, partially hydrolysed with hypoallergenic label [pHF‐HA], extensively hydrolysed [eHF], soya) and solid food introduction were collected using repeated questionnaires at 1, 3, 6, 9 and 12 months. Infants with similar feeding practices over the first year of life were grouped using multidimensional longitudinal cluster analysis. Respiratory/allergic morbidity was studied at 8 years as symptoms, doctor's diagnoses (asthma, hay fever, eczema, food allergy), and measurement of lung function, FeNO and specific IgE. Associations between feeding‐related clusters and respiratory/allergic morbidity were investigated using multivariable logistic and linear regression models adjusted for potential confounders including early respiratory/allergic outcomes and parental history of allergy. Results: Five clusters were identified among 3446 infants: Cluster 1 (45%) mainly fed with regular formula, Cluster 2 (27%) exclusively breastfed during the first 3 months, and three other clusters consuming different types of formula (pre‐/probiotics for Cluster 3 [17%], pHF‐HA for Cluster 4 [7%], eHF/soya for Cluster 5 [4%]). Compared to Cluster 1, children from Cluster 2 tended to have a lower risk of asthma and children from Cluster 4 had a significant lower lung function (FEV1, FVC), higher FeNO and higher risk of sensitization at 8 years. Conclusion: Early pHF‐HA use was negatively associated with objective measures of respiratory/allergic morbidity at school age, while children breastfed for at least 3 months seem protected against asthma at 8 years old.
- Subjects
PARIS (France); RESPIRATORY allergy; INFANTS; INFANT formulas; FOOD allergy; ASTHMA in children; ECZEMA; ALLERGIC rhinitis
- Publication
Allergy, 2021, Vol 76, Issue 4, p1223
- ISSN
0105-4538
- Publication type
Article
- DOI
10.1111/all.14568