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- Title
Limited impact of Der p 23 IgE on treatment outcomes in tablet allergy immunotherapy phase III study.
- Authors
Stranzl, Thomas; Ipsen, Henrik; Christensen, Lars Harder; Eiwegger, Thomas; Johansen, Niels; Lund, Kaare; Andersen, Peter Sejer
- Abstract
Keywords: cinical effect; Der p 23; diagnosis; HDM SLIT-tablets EN cinical effect Der p 23 diagnosis HDM SLIT-tablets 1235 1238 4 04/14/21 20210401 NES 210401 Allergen 23 from I Dermatophagoides pteronyssinus i (Der p 23) has recently been identified as a novel major house dust mite (HDM) allergen based on the high prevalence of Der p 23-specific IgE in HDM-sensitized individuals.1 The clinical importance of Der p 23 sensitization is unknown. +:allergen-specific IgE > 0.7kUA/L; -:allergen-specific IgE < 0.7kUA/L. a:Der p 1 and/or Der p 2 IgE; b:Der p 1 and/or Der p 2 and/or Der p 23 IgE. A similar observation was made in a different population.3 GLO:1X5/01apr21:all14200-fig-0001.jpg PHOTO (COLOR): 1 A, IgE sensitization frequencies: Der p 1, Der p 2, Der p 10 and Der p 23 (blue), combined Der p 1 and Der p 2 sensitization with and without Der p 10 and Der p 23 (orange, red). The mean level of Der p 23 IgE in the MITRA population is 2.5- to 3.5-fold lower compared with Der p 1 and 2, and even below the level of IgE specific for the minor allergen Der p 10 (Figure 1B).
- Subjects
TREATMENT effectiveness; ALLERGIES; HOUSE dust mites; IMMUNOTHERAPY
- Publication
Allergy, 2021, Vol 76, Issue 4, p1235
- ISSN
0105-4538
- Publication type
Article
- DOI
10.1111/all.14200