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- Title
Effect of Semen Sampling Frequency on Seminal Antiretroviral Drug Concentration.
- Authors
Cao, Y. J.; Ndovi, T. T.; Parsons, T. L.; Guidos, A. M.; Caffo, B.; Hendrix, C. W.
- Abstract
Study of male genital tract (MGT) pharmacology is relevant to the treatment of prostatitis, prostate cancer, infertility, and seminal human immunodeficiency virus transmission. However, the time course of drug concentrations in the MGT is largely unknown. To determine the feasibility of frequent semen sampling in assessing the pharmacokinetics of the MGT, we administered efavirenz, indinavir, and zidovudine to subjects to achieve steady-state levels and then collected semen samples at sequentially decreasing ejaculation intervals. The volume of seminal plasma decreased from 4.0 (1.2–5.1) ml (median with range) at 48 h after the baseline ejaculation to 0.72 (0.45–1.6) ml 1 h after a previous ejaculation, which was still adequate for drug concentration assessment. The seminal fructose concentration also decreased. However, the concentration of prostate-specific antigen and all three drugs did not decrease, even if the ejaculation intervals decreased to 1 h. Thus, semi-intensive semen sampling can be used to assess MGT pharmacokinetics.Clinical Pharmacology & Therapeutics (2008); 83, 6, 848–856 doi:10.1038/sj.clpt.6100356
- Subjects
CANCER treatment; CANCER education; PHYSIOLOGICAL effects of chemicals; DRUGS; EJACULATION; PHARMACOLOGY
- Publication
Clinical Pharmacology & Therapeutics, 2008, Vol 83, Issue 6, p848
- ISSN
0009-9236
- Publication type
Article
- DOI
10.1038/sj.clpt.6100356