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- Title
PIII-34.
- Authors
Marunde, R.; Jin, Y.; Ayaji, O.; Neville, K.; Phillips, S.; Skaar, T. C.; Hall, S. D.
- Abstract
Background/aims: Previous reports suggest that cytochrome P450 3A5 (CYP3A5) expression is associated with hypertension. We examined whether this association is also present in a group of young Nigerian males.Methods: DNA samples and blood pressure data were collected from 106 Nigerian males. Blood pressure was determined by manual sphygmomanometry. CYP3A5*3, *6 and *7 single nucleotide polymorphisms (SNPs) were identified using real time PCR. Four common haplotypes were constructed from the SNP data: *1, *3, *6, *7 with PHASE II. Based on the haplotype, subjects were classified into homozygote expressors (*1/*1), heterozygote expressors (*1/*0) and nonexpressors (*0/*0). Clinical characteristics among subjects with different CYP3A5 genotypes were compared with ANOVA using SPSS.Results: Allele frequencies for *1, *3, *6 and *7 in this Nigerian population are 56.4%, 15.8%, 9.4% and 14.9%, respectively. We did not detect any difference in systolic, diastolic and mean arterial blood pressure between CYP3A5 genotypes (table 1).Conclusion: In addition to the CYP3A5*3 allele, the non-expressing *6 and *7 alleles were very prevalent in this Nigerian population. We did not identify any association between the CYP3A5 genotypes and blood pressure in this population.Clinical Pharmacology & Therapeutics (2005) 79, P67–P67; doi: 10.1016/j.clpt.2005.12.242
- Subjects
NIGERIANS; DNA; BLOOD pressure; HYPERTENSION; GENETIC polymorphisms; CARDIAC contraction; PHYSIOLOGY
- Publication
Clinical Pharmacology & Therapeutics, 2006, Vol 79, Issue 2, pP67
- ISSN
0009-9236
- Publication type
Article
- DOI
10.1016/j.clpt.2005.12.242