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- Title
Localization and restaging of carcinoma prostate by <sup>68</sup>Gallium prostate-specific membrane antigen positron emission tomography computed tomography in patients with biochemical recurrence.
- Authors
Seniaray, Nikhil; Verma, Ritu; Khanna, Sudhir; Belho, Ethel; Pruthi, Ankur; Mahajan, Harsh
- Abstract
Introduction: Radical prostatectomy (RP) and radical radiotherapy (RT) are well established primary curative options for localized prostate cancer. Despite technical improvements, prostate-specific antigen (PSA)-recurrence after RP and RT is a common clinical scenario. We aimed to assess the role of 68Gallium (68Ga) prostate-specific membrane antigen positron emission tomography computed tomography (PSMA PET/CT) in patients with biochemical recurrence of prostate cancer after RP or RT for the detection and localization recurrent and metastatic disease. Materials and Methods: We ambispectively (70 retrospective and 100 prospective) analyzed the data of men with biochemical recurrence post-RP and post-RT who were evaluated by 68Ga PSMA PET/CT at our institute. We aimed to assess the relationship between serum PSA levels and the probability of having a positive scan in patients with recurrent prostate cancer. Results: The study included 170 men, all had adenocarcinoma of the prostate, 124/170 had previous RP and 46/170 had prior RT. The median serum PSA in the RP group was 1.8 ng/ml and 5.2 ng/ml in the RT group. In the post-RP cohort, the detection rate of 68Ga PSMA PET/CT was 39.3% for PSA 0.2 to <0.5 ng/ml, 47.3% for PSA 0.5 to <1 ng/ml, 68.4% for PSA 1 to <2 ng/ml and 93.1% for PSA ≥2 ng/ml. In the post-RT group, the detection rate was 88.8% for PSA 2 to <4 ng/ml and 100% for PSA ≥4 ng/ml. Conclusions: 68Ga PSMA PET/CT provides a novel imaging modality for the detection of prostate cancer recurrence and metastases at low posttreatment PSA levels, which may help in directing appropriate salvage treatments.
- Subjects
CANCER treatment; PROSTATE tumors treatment; PROSTATE-specific antigen; CANCER relapse; RADIOTHERAPY; COMPUTED tomography; RADICAL prostatectomy; GALLIUM; RETROSPECTIVE studies; METASTASIS; LONGITUDINAL method; PROSTATE-specific membrane antigen; EMISSION-computed tomography; TUMOR classification
- Publication
Indian Journal of Urology, 2020, Vol 36, Issue 3, p191
- ISSN
0970-1591
- Publication type
Article
- DOI
10.4103/iju.IJU_275_19