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- Title
Mapping non-class II H2-linked loci for type 1 diabetes in nonobese diabetic mice.
- Authors
Deruytter, Nathalie; Boulard, Olivier; Garchon, Henri-Jean
- Abstract
Major histocompatibility complex (MHC) plays a largely predominant role in the genetic predisposition to type 1 diabetes, in both humans and rodents. While class II loci have long been recognized as essential, they do not fully explain the MHC-linked genetic component of type 1 diabetes. In the present study, using new NOD congenic strains harboring defined chromosomal segments from C57BL/6 mice, we circumscribed three distinct loci influencing murine type 1 diabetes and tightly linked to but separated from the class II region. Our findings might guide the search for additional HLA-linked loci in human type 1 diabetes.
- Subjects
DIABETES; CHROMOSOMES; HISTOCOMPATIBILITY; GENETICS; IMMUNOGENETICS; ANIMAL experimentation; COMPARATIVE studies; DISEASE susceptibility; GENE mapping; GENES; HISTOCOMPATIBILITY antigens; TYPE 1 diabetes; RESEARCH methodology; MEDICAL cooperation; MICE; RESEARCH; GENETIC markers; EVALUATION research
- Publication
Diabetes, 2004, Vol 53, Issue 12, p3323
- ISSN
0012-1797
- Publication type
journal article
- DOI
10.2337/diabetes.53.12.3323