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- Title
Evaluation of the Osteoblast Behavior to PGA Textile Functionalized with RGD as a Scaffold for Bone Regeneration.
- Authors
Ortiz, Mariné; Escobar-Garcia, Diana María; Álvarez-Pérez, Marco Antonio; Pozos-Guillén, Amaury; Grandfils, Christian; Flores, Héctor
- Abstract
The new era of biomaterials for repairing bone tissue injury continues to be a challenge in bone tissue engineering. The fiber scaffolds allow for cellular interconnection and a microenvironment close to the bone extracellular matrix. The aim of this study was to evaluate the osteoblast behavior on a 3D textile of PGA (polyglycolic acid) fibers functionalized with the RGD (R: arginine; G: glycine; D: aspartic acid) peptide. The cell morphology, proliferation, and calcium phosphate deposition ability were evaluated on textiles at different time intervals under a confocal laser scanning microscope. The osteoblast viability ranged from 92% to 98%, and cell proliferation was higher in PGA-RGD than control PGA (uncoated). In addition, the osteoblast calcium phosphate deposition was significantly greater on PGA-RGD in osteogenic inductor medium (OIM) in contrast to controls without inducing factors. The PGA-RGD fibers supported proliferation and viability of osteoblast and stimulated bone osteogenesis and mineralization. These results support the adoption of this 3D polymeric textile as a scaffold for bone tissue engineering.
- Subjects
POLYLACTIC acid; TISSUE scaffolds; OSTEOBLASTS; BONE regeneration; EXTRACELLULAR matrix; MEDICAL imaging systems; THREE-dimensional imaging
- Publication
Journal of Nanomaterials, 2017, p1
- ISSN
1687-4110
- Publication type
Article
- DOI
10.1155/2017/4852190