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- Title
Preoperative administration of branched-chain amino acids reduces postoperative insulin resistance in rats by reducing liver gluconeogenesis.
- Authors
Zhang, Jin; Chi, Rui; Zhang, Yunpeng; Xie, Yi; Liu, Yunxia; Bao, Qun; Lv, Hengyu; Han, Bo; Sun, Haipeng; Sun, Peng
- Abstract
Background: Postoperative insulin resistance (PIR) represents an important characteristic of metabolic response following surgical injury. Clinical outcomes are negatively correlated to postoperative insulin resistance and hyperglycemia, indicating a novel treatment for reducing postoperative insulin resistance is urgently needed. The current work aimed to assess the protective effects of branched-chain amino acids (BCAA) on glucose metabolism disorders induced surgically in a rat model, and to explore the underpinning mechanism. Methods and results: Rats were randomly assigned to 2 groups, including the control and BCAA groups. Rats were given a compulsory oral 3 mL load by gavage two hours before surgery. The results showed that BCAA remarkably reduced glycemia by suppressing liver gluconeogenesis via reduction of cAMP-response element-binding protein-regulated transcription coactivator 2 (CRTC2) and glucose-6-phosphatase (G6PC) gene and protein expression levels (all Ps < 0.05). Conclusions: This study revealed that BCAA lower blood glucose levels by reducing liver gluconeogenesis without significant elevation of plasma insulin levels. We anticipate that preoperative BCAA supplementation may be a means for preventing postoperative insulin resistance.
- Subjects
GLUCOSE metabolism; PREVENTION of surgical complications; HYPERGLYCEMIA prevention; PREOPERATIVE care; BIOLOGICAL models; BRANCHED chain amino acids; CARBOHYDRATE metabolism; ANALYSIS of variance; LIVER; ANIMAL experimentation; PHOSPHATASES; BLOOD sugar; RATS; GENE expression; INSULIN; DESCRIPTIVE statistics; GLUCOSE; TRANSCRIPTION factors; MOLECULAR structure; INSULIN resistance
- Publication
Nutrition & Metabolism, 2022, Vol 19, Issue 1, p1
- ISSN
1743-7075
- Publication type
Article
- DOI
10.1186/s12986-022-00710-3