We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Systemic immunosuppression depletes peripheral blood regulatory B cells in patients with immune thrombocytopenia.
- Authors
Stimpson, Madeleine L.; Wolf, Julia; Charbit, Bruno; Williams, Emily L.; Lait, Philippa J. P.; Schewitz‐Bowers, Lauren P.; Lee, Richard W. J.; Bradbury, Charlotte A.
- Abstract
Summary: Regulatory B (Breg) cells are potentially implicated in the pathogenesis of immune thrombocytopenia (ITP). We analysed a prospective cohort of newly diagnosed steroid naïve ITP patients enrolled in the multicentre FLIGHT trial and found that the numbers of Bregs in their peripheral blood were similar to healthy controls. In contrast, Breg numbers were significantly reduced in ITP patients treated with systemic immunosuppression (glucocorticoids or mycophenolate mofetil). We also demonstrate that glucocorticoid treatment impairs Breg interleukin‐10 production via an indirect T‐cell‐mediated mechanism.
- Subjects
REGULATORY B cells; IDIOPATHIC thrombocytopenic purpura; IMMUNOSUPPRESSION; MYCOPHENOLIC acid
- Publication
British Journal of Haematology, 2024, Vol 204, Issue 2, p644
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/bjh.19144