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The DUF1669 domain of FAM83 family proteins anchor casein kinase 1 isoforms.
Published in:
Science Signaling, 2018, v. 11, n. 531, p. 1, doi. 10.1126/scisignal.aao2341
By:
- Fulcher, Luke J.;
- Bozatzi, Polyxeni;
- Tachie-Menson, Theresa;
- Wu, Kevin Z. L.;
- Cummins, Timothy D.;
- Bufton, Joshua C.;
- Pinkas, Daniel M.;
- Dunbar, Karen;
- Shrestha, Sabin;
- Wood, Nicola T.;
- Weidlich, Simone;
- Macartney, Thomas J.;
- Varghese, Joby;
- Gourlay, Robert;
- Campbell, David G.;
- Dingwell, Kevin S.;
- Smith, James C.;
- Bullock, Alex N.;
- Sapkota, Gopal P.
Publication type:
Article
Sequence and structural variations determining the recruitment of WNK kinases to the KLHL3 E3 ligase.
Published in:
Biochemical Journal, 2022, v. 479, n. 5, p. 661, doi. 10.1042/BCJ20220019
By:
- Zhuoyao Chen;
- Jinwei Zhang;
- Murillo-de-Ozores, Adrián R.;
- Castañeda-Bueno, María;
- D'Amico, Francesca;
- Heilig, Raphael;
- Manning, Charlotte E.;
- Sorrell, Fiona J.;
- D'Angiolella, Vincenzo;
- Fischer, Roman;
- Mulder, Monique P. C.;
- Gamba, Gerardo;
- Alessi, Dario R.;
- Bullock, Alex N.
Publication type:
Article
Lessons from LIMK1 enzymology and their impact on inhibitor design.
Published in:
Biochemical Journal, 2019, v. 476, n. 21, p. 3197, doi. 10.1042/BCJ20190517
By:
- Salah, Eidarus;
- Chatterjee, Deep;
- Beltrami, Alessandra;
- Tumber, Anthony;
- Preuss, Franziska;
- Canning, Peter;
- Chaikuad, Apirat;
- Knaus, Petra;
- Knapp, Stefan;
- Bullock, Alex N.;
- Mathea, Sebastian
Publication type:
Article
Structural complexity in the KCTD family of Cullin3-dependent E3 ubiquitin ligases.
Published in:
Biochemical Journal, 2017, v. 474, n. 22, p. 3747, doi. 10.1042/BCJ20170527
By:
- Pinkas, Daniel M.;
- Sanvitale, Caroline E.;
- Bufton, Joshua C.;
- Sorrell, Fiona J.;
- Solcan, Nicolae;
- Chalk, Rod;
- Doutch, James;
- Bullock, Alex N.
Publication type:
Article
Structure and inhibitor specificity of the PCTAIRE-family kinase CDK16.
Published in:
Biochemical Journal, 2017, v. 474, n. 5, p. 699, doi. 10.1042/BCJ20160941
By:
- Dixon-Clarke, Sarah E.;
- Shehata, Saifeldin N.;
- Krojer, Tobias;
- Sharpe, Timothy D.;
- von Delft, Frank;
- Kei Sakamoto;
- Bullock, Alex N.
Publication type:
Article
Structural and biochemical characterization of the KLHL3-WNK kinase interaction important in blood pressure regulation.
Published in:
Biochemical Journal, 2014, v. 460, n. 2, p. 237, doi. 10.1042/BJ20140153
By:
- SCHUMACHER, Frances-Rose;
- SORRELL, Fiona J.;
- ALESSI, Dario R.;
- BULLOCK, Alex N.;
- KURZ, Thimo
Publication type:
Article
Development of Macrocycle Kinase Inhibitors for ALK2 Using Fibrodysplasia Ossificans Progressiva‐Derived Endothelial Cells.
Published in:
JBMR Plus, 2019, v. 3, n. 11, p. N.PAG, doi. 10.1002/jbm4.10230
By:
- Sánchez‐Duffhues, Gonzalo;
- Williams, Eleanor;
- Benderitter, Pascal;
- Orlova, Valeria;
- Wijhe, Michiel;
- Garcia de Vinuesa, Amaya;
- Kerr, Georgina;
- Caradec, Josselin;
- Lodder, Kirsten;
- Boer, Hetty C.;
- Goumans, Marie‐José;
- Eekhoff, Elisabeth M W;
- Morales‐Piga, Antonio;
- Bachiller‐Corral, Javier;
- Koolwijk, Pieter;
- Bullock, Alex N.;
- Hoflack, Jan;
- Dijke, Peter
Publication type:
Article
The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation.
Published in:
EMBO Journal, 2008, v. 27, n. 13, p. 1907, doi. 10.1038/emboj.2008.121
By:
- Baumli, Sonja;
- Lolli, Graziano;
- Lowe, Edward D.;
- Troiani, Sonia;
- Rusconi, Luisa;
- Bullock, Alex N.;
- Debreczeni, Judit É.;
- Knapp, Stefan;
- Johnson, Louise N.
Publication type:
Article
New potent dual inhibitors of CK2 and Pim kinases: discovery and structural insights.
Published in:
FASEB Journal, 2010, v. 24, n. 9, p. 3171, doi. 10.1096/fj.09-143743
By:
- López-Ramos, Miriam;
- Prudent, Renaud;
- Moucadel, Virginie;
- Sautel, Céline F.;
- Barette, Caroline;
- Lafanechère, Laurence;
- Mouawad, Liliane;
- Grierson, David;
- Schmidt, Frédéric;
- Florent, Jean-Claude;
- Filippakopoulos, Panagis;
- Bullock, Alex N.;
- Knapp, Stefan;
- Reiser, Jean-Baptiste;
- Cochet, Claude
Publication type:
Article
Crystal Structure-Guided Design of Bisubstrate Inhibitors and Photoluminescent Probes for Protein Kinases of the PIM Family.
Published in:
Molecules, 2021, v. 26, n. 14, p. 4353, doi. 10.3390/molecules26144353
By:
- Nonga, Olivier E.;
- Lavogina, Darja;
- Enkvist, Erki;
- Kestav, Katrin;
- Chaikuad, Apirat;
- Dixon-Clarke, Sarah E.;
- Bullock, Alex N.;
- Kopanchuk, Sergei;
- Ivan, Taavi;
- Ekambaram, Ramesh;
- Viht, Kaido;
- Knapp, Stefan;
- Uri, Asko
Publication type:
Article
Clinical Utility Gene Card for: Fibrodysplasia ossificans progressiva.
Published in:
European Journal of Human Genetics, 2015, v. 23, n. 10, p. -1, doi. 10.1038/ejhg.2014.274
By:
- Bravenboer, Nathalie;
- Micha, Dimitra;
- Triffit, James T;
- Bullock, Alex N;
- Ravazollo, Roberto;
- Bocciardi, Renata;
- di Rocco, Maja;
- Netelenbos, J Coen;
- Ten Dijke, Peter;
- Sánchez-Duffhues, Gonzalo;
- Kaplan, Fred S;
- Shore, Eileen M;
- Pignolo, Robert J;
- Seemann, Petra;
- Ventura, Francesc;
- Beaujat, Genevieve;
- Eekhoff, Elizabeth M W;
- Pals, Gerard
Publication type:
Article
Challenges and Opportunities for Drug Repositioning in Fibrodysplasia Ossificans Progressiva.
Published in:
Biomedicines, 2021, v. 9, n. 2, p. 213, doi. 10.3390/biomedicines9020213
By:
- Ventura, Francesc;
- Williams, Eleanor;
- Ikeya, Makoto;
- Bullock, Alex N.;
- ten Dijke, Peter;
- Goumans, Marie-José;
- Sanchez-Duffhues, Gonzalo;
- Ravazzolo, Roberto
Publication type:
Article
ALK2 Receptor Kinase Association with FKBP12.6 Is Structurally Conserved with the ALK2-FKBP12 Complex.
Published in:
Biomedicines, 2021, v. 9, n. 2, p. 129, doi. 10.3390/biomedicines9020129
By:
- Williams, Eleanor;
- Riesebos, Elise;
- Kerr, Georgina;
- Bullock, Alex N.;
- Ravazzolo, Roberto
Publication type:
Article
Structural consequences of BMPR2 kinase domain mutations causing pulmonary arterial hypertension.
Published in:
Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-54830-7
By:
- Chaikuad, Apirat;
- Thangaratnarajah, Chancievan;
- von Delft, Frank;
- Bullock, Alex N.
Publication type:
Article
Ruthenium Half-Sandwich Complexes Bound to Protein Kinase Pim-1We gratefully acknowledge support for this work from the US National Institutes of Health through grant 1 R01 GM071695-01A1 (E.M.). The Structural Genomics Consortium is a registered charity (no. 1097737) funded by the Wellcome Trust, GlaxoSmithKline, Genome Canada, the Canadian Institutes of Health Research, the Ontario Innovation Trust, the Ontario Research and Development Challenge Fund, and the Canadian Foundation for Innovation.
Published in:
Angewandte Chemie International Edition, 2006, v. 45, n. 10, p. 1580, doi. 10.1002/anie.200503468
By:
- Judit É. Debreczeni;
- Alex N. Bullock;
- G. Ekin Atilla;
- Douglas S. Williams;
- Howard Bregman;
- Stefan Knapp;
- Eric Meggers
Publication type:
Article
RESCUING THE FUNCTION OF MUTANT p53.
Published in:
Nature Reviews Cancer, 2001, v. 1, n. 1, p. 68, doi. 10.1038/35094077
By:
- Bullock, Alex N.;
- Fersht, Alan R.
Publication type:
Article
Mutations in Known Monogenic High Bone Mass Loci Only Explain a Small Proportion of High Bone Mass Cases.
Published in:
Journal of Bone & Mineral Research, 2016, v. 31, n. 3, p. 640, doi. 10.1002/jbmr.2706
By:
- Gregson, Celia L;
- Wheeler, Lawrie;
- Hardcastle, Sarah A;
- Appleton, Louise H;
- Addison, Kathryn A;
- Brugmans, Marieke;
- Clark, Graeme R;
- Ward, Kate A;
- Paggiosi, Margaret;
- Stone, Mike;
- Thomas, Joegi;
- Agarwal, Rohan;
- Poole, Kenneth ES;
- McCloskey, Eugene;
- Fraser, William D;
- Williams, Eleanor;
- Bullock, Alex N;
- Davey Smith, George;
- Brown, Matthew A;
- Tobias, Jon H
Publication type:
Article
Target highlights in CASP13: Experimental target structures through the eyes of their authors.
Published in:
Proteins, 2019, v. 87, n. 12, p. 1037, doi. 10.1002/prot.25805
By:
- Lepore, Rosalba;
- Kryshtafovych, Andriy;
- Alahuhta, Markus;
- Veraszto, Harshul A.;
- Bomble, Yannick J.;
- Bufton, Joshua C.;
- Bullock, Alex N.;
- Caba, Cody;
- Cao, Hongnan;
- Davies, Owen R.;
- Desfosses, Ambroise;
- Dunne, Matthew;
- Fidelis, Krzysztof;
- Goulding, Celia W.;
- Gurusaran, Manickam;
- Gutsche, Irina;
- Harding, Christopher J.;
- Hartmann, Marcus D.;
- Hayes, Christopher S.;
- Joachimiak, Andrzej
Publication type:
Article
Protocol paper: a multi-center, double-blinded, randomized, 6-month, placebo-controlled study followed by 12-month open label extension to evaluate the safety and efficacy of Saracatinib in Fibrodysplasia Ossificans Progressiva (STOPFOP).
Published in:
2022
By:
- Smilde, Bernard J.;
- Stockklausner, Clemens;
- Keen, Richard;
- Whittaker, Andrew;
- Bullock, Alex N.;
- von Delft, Annette;
- van Schoor, Natasja M.;
- Yu, Paul B.;
- Eekhoff, E. Marelise W.
Publication type:
journal article
Ruthenium Half-Sandwich Complexes Bound to Protein Kinase Pim-1We gratefully acknowledge support for this work from the US National Institutes of Health through grant 1 R01 GM071695-01A1 (E.M.). The Structural Genomics Consortium is a registered charity (no. 1097737) funded by the Wellcome Trust, GlaxoSmithKline, Genome Canada, the Canadian Institutes of Health Research, the Ontario Innovation Trust, the Ontario Research and Development Challenge Fund, and the Canadian Foundation for Innovation.
Published in:
Angewandte Chemie, 2006, v. 118, n. 10, p. 1610, doi. 10.1002/ange.200503468
By:
- Judit É. Debreczeni;
- Alex N. Bullock;
- G. Ekin Atilla;
- Douglas S. Williams;
- Howard Bregman;
- Stefan Knapp;
- Eric Meggers
Publication type:
Article
PRMT5 inhibition shows in vitro efficacy against H3K27M-altered diffuse midline glioma, but does not extend survival in vivo.
Published in:
Scientific Reports, 2024, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-48652-x
By:
- Brown, Elizabeth J.;
- Balaguer-Lluna, Leire;
- Cribbs, Adam P.;
- Philpott, Martin;
- Campo, Leticia;
- Browne, Molly;
- Wong, Jong Fu;
- Oppermann, Udo;
- Carcaboso, Ángel M.;
- Bullock, Alex N.;
- Farnie, Gillian
Publication type:
Article
Suppressor of Cytokine Signaling (SOCS) 5 Utilises Distinct Domains for Regulation of JAK1 and Interaction with the Adaptor Protein Shc-1.
Published in:
PLoS ONE, 2013, v. 8, n. 8, p. 1, doi. 10.1371/journal.pone.0070536
By:
- Linossi, Edmond M.;
- Chandrashekaran, Indu R.;
- Kolesnik, Tatiana B.;
- Murphy, James M.;
- Webb, Andrew I.;
- Willson, Tracy A.;
- Kedzierski, Lukasz;
- Bullock, Alex N.;
- Babon, Jeffrey J.;
- Norton, Raymond S.;
- Nicola, Nicos A.;
- Nicholson, Sandra E.
Publication type:
Article
A New Class of Small Molecule Inhibitor of BMP Signaling.
Published in:
PLoS ONE, 2013, v. 8, n. 4, p. 1, doi. 10.1371/journal.pone.0062721
By:
- Sanvitale, Caroline E.;
- Kerr, Georgina;
- Chaikuad, Apirat;
- Ramel, Marie-Christine;
- Mohedas, Agustin H.;
- Reichert, Sabine;
- Wang, You;
- Triffitt, James T.;
- Cuny, Gregory D.;
- Yu, Paul B.;
- Hill, Caroline S.;
- Bullock, Alex N.
Publication type:
Article
Crystal Structure of the PIM2 Kinase in Complex with an Organoruthenium Inhibitor.
Published in:
PLoS ONE, 2009, v. 4, n. 10, p. 1, doi. 10.1371/journal.pone.0007112
By:
- Bullock, Alex N.;
- Russo, Santina;
- Amos, Ann;
- Pagano, Nicholas;
- Bregman, Howard;
- Debreczeni, Judit É.;
- Lee, Wen Hwa;
- Delft, Frank von;
- Meggers, Eric;
- Knapp, Stefan
Publication type:
Article
Novel Mutations in ACVR1 Result in Atypical Features in Two Fibrodysplasia Ossificans Progressiva Patients.
Published in:
PLoS ONE, 2009, v. 4, n. 3, p. 1, doi. 10.1371/journal.pone.0005005
By:
- Petrie, Kirsten A.;
- Wen Hwa Lee;
- Bullock, Alex N.;
- Pointon, Jenny J.;
- Smith, Roger;
- Russell, R. Graham G.;
- Brown, Matthew A.;
- Wordsworth, B. Paul;
- Triffitt, James T.
Publication type:
Article
Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin-dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiology.
Published in:
eLife, 2023, p. 1, doi. 10.7554/eLife.88206
By:
- Castano, Anna;
- Silvestre, Margaux;
- Wells, Carrow I.;
- Sanderson, Jennifer L.;
- Ferrer, Carla A.;
- Han Wee Ong;
- Yi Lang;
- Richardson, William;
- Silvaroli, Josie A.;
- Bashore, Frances M.;
- Smith, Jeffery L.;
- Genereux, Isabelle M.;
- Dempster, Kelvin;
- Drewry, David H.;
- Pabla, Navlot S.;
- Bullock, Alex N.;
- Benke, Tim A.;
- Ultanir, Sila K.;
- Axtman, Alison D.
Publication type:
Article
Synthesis of Highly Water-Soluble Adamantyl Phosphoinositide Derivatives.
Published in:
Australian Journal of Chemistry, 2015, v. 68, n. 4, p. 543, doi. 10.1071/CH14543
By:
- Gregory, Mark;
- Meng-Xin Yin;
- McConville, Malcolm J.;
- Williams, Eleanor;
- Bullock, Alex N.;
- Conway, Stuart J.;
- Burgess, Antony W.;
- Catimel, Bruno;
- Holmes, Andrew B.
Publication type:
Article
Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma.
Published in:
Nature Genetics, 2014, v. 46, n. 5, p. 457, doi. 10.1038/ng.2925
By:
- Taylor, Kathryn R;
- Mackay, Alan;
- Truffaux, Nathalène;
- Butterfield, Yaron S;
- Morozova, Olena;
- Philippe, Cathy;
- Castel, David;
- Grasso, Catherine S;
- Vinci, Maria;
- Carvalho, Diana;
- Carcaboso, Angel M;
- de Torres, Carmen;
- Cruz, Ofelia;
- Mora, Jaume;
- Entz-Werle, Natacha;
- Ingram, Wendy J;
- Monje, Michelle;
- Hargrave, Darren;
- Bullock, Alex N;
- Puget, Stéphanie
Publication type:
Article
Quantitative analysis of residual folding and DNA binding in mutant p53 core domain: definition of mutant states for rescue in cancer therapy.
Published in:
Oncogene, 2000, v. 19, n. 10, p. 1245, doi. 10.1038/sj.onc.1203434
By:
- Bullock, Alex N;
- Henckel, Julia;
- Fersht, Alan R
Publication type:
Article
Computational redesign of protein-protein interaction specificity.
Published in:
Nature Structural & Molecular Biology, 2004, v. 11, n. 4, p. 371, doi. 10.1038/nsmb749
By:
- Kortemme, Tanja;
- Joachimiak, Lukasz A.;
- Bullock, Alex N.;
- Schuler, Aaron D.;
- Stoddard, Barry L.;
- Baker, David
Publication type:
Article
The SGC beyond structural genomics: redefining the role of 3D structures by coupling genomic stratification with fragment-based discovery.
Published in:
Essays in Biochemistry, 2017, v. 61, n. 5, p. 495, doi. 10.1042/EBC20170051
By:
- Bradley, Anthony R.;
- Echalier, Aude;
- Fairhead, Michael;
- Strain-Damerell, Claire;
- Brennan, Paul;
- Bullock, Alex N.;
- Burgess-Brown, Nicola A.;
- Carpenter, Elisabeth P.;
- Gileadi, Opher;
- Marsden, Brian D.;
- Wen Hwa Lee;
- Yue, Wyatt;
- Bountra, Chas;
- von Delft, Frank
Publication type:
Article
Fostering open collaboration in drug development for paediatric brain tumours.
Published in:
Biochemical Society Transactions, 2019, v. 47, n. 5, p. 1471, doi. 10.1042/BST20190315
By:
- Jong Fu Wong;
- Brown, Elizabeth J.;
- Williams, Eleanor;
- Bullock, Alex N.
Publication type:
Article
New strategies to inhibit KEAP1 and the Cul3-based E3 ubiquitin ligases.
Published in:
Biochemical Society Transactions, 2014, v. 42, n. 1, p. 103, doi. 10.1042/BST20130215
By:
- Canning, Peter;
- Bullock, Alex N.
Publication type:
Article
Structures of the CDK12/CycK complex with AMP-PNP reveal a flexible C-terminal kinase extension important for ATP binding.
Published in:
Scientific Reports, 2015, p. 17122, doi. 10.1038/srep17122
By:
- Dixon-Clarke, Sarah E.;
- Elkins, Jonathan M.;
- Cheng, S.-W. Grace;
- Morin, Gregg B.;
- Bullock, Alex N.
Publication type:
Article
Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling.
Published in:
EMBO Journal, 2018, v. 37, n. 17, p. 1, doi. 10.15252/embj.201899372
By:
- Hrdinka, Matous;
- Schlicher, Lisa;
- Dai, Bing;
- Pinkas, Daniel M.;
- Bufton, Joshua C.;
- Picaud, Sarah;
- Ward, Jennifer A.;
- Rogers, Catherine;
- Suebsuwong, Chalada;
- Nikhar, Sameer;
- Cuny, Gregory D.;
- Huber, Kilian V. M.;
- Filippakopoulos, Panagis;
- Bullock, Alex N.;
- Degterev, Alexei;
- Gyrd‐Hansen, Mads
Publication type:
Article

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