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- Title
Intratumoral heterogeneity contributes to the chemotherapy prognosis of breast cancer.
- Authors
Li, Yang; Wang, Maohua; Yang, Siyuan; Kuang, Licheng; Tao, Xinling; Yang, Jilan; Zhao, Wentao; Zhang, Ji
- Abstract
<bold>Context: </bold>Previous studies have shown that intratumoral heterogeneity (ITH) is associated with poor clinical outcomes and is thought to be a mechanism of resistance to chemotherapy and radiotherapy.<bold>Aims: </bold>We aimed to determine how ITH affects the response to drug therapy in breast cancer (BC).<bold>Settings and Design: </bold>We assessed ITH using mutated allele tumor heterogeneity (MATH) data from BC patients in the TCGA database.<bold>Methods and Material: </bold>The study enrolled 515 patients with BC treated with chemotherapy from the TCGA database who had available data on survival, whole-exome sequencing, and genome-wide transcriptome sequencing. Additionally, 399 MSK-BRCA cohort patients were treated with chemotherapy.<bold>Statistical Analysis Used: </bold>All statistical analyses were conducted using R. All comparisons were made using the two-sided Mann-Whitney test, Pearson's Chi-squared test, and the Kruskal-Wallis test. Statistical significance was defined as P values less than 0.05 (*P < 0.05). The survival package in R was used to conduct the analysis.<bold>Results: </bold>Additional analysis was performed on 515 BC patients receiving adjuvant chemotherapy. MATH was associated with overall survival (OS) in multivariate analysis (hazard ratio (HR), 1.432; 95% confidence interval, 1.073-1.913; P = 0.015). Pathway enrichment and immune cell analysis revealed that the low MATH group had significantly higher infiltration of 24 different types of immune cells than the high MATH group.<bold>Conclusions: </bold>Individuals with low MATH scores had a longer OS than those with high MATH scores. Immune responses were significantly enhanced in breast cancer patients with low MATH scores.
- Subjects
ADJUVANT chemotherapy; ARTHRITIS Impact Measurement Scales; PROGNOSIS; BREAST tumors; PROPORTIONAL hazards models; LONGITUDINAL method
- Publication
Journal of Cancer Research & Therapeutics, 2022, Vol 18, Issue 5, p1268
- ISSN
0973-1482
- Publication type
Article
- DOI
10.4103/jcrt.jcrt_1166_21