We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Comparison of radiation and chemoradiation-induced sensorineural hearing loss in head and neck cancer patients.
- Authors
Mahdavi, Seied Rabi; Rezaeyan, Abolhasan; Nikoofar, Alireza; Bakhshandeh, Mohsen; Farahani, Saeid; Cheraghi, Susan
- Abstract
<bold>Aim: </bold>The purpose of this study was to assess and compare the incidence and severity of sensorineural hearing loss (SNHL) in head-and-neck patients undergoing radiotherapy (RT) and concurrent cisplatin-based chemoradiotherapy (CRT).<bold>Materials and Methods: </bold>Pure tone audiometry (PTA) was performed at 0.25-12 kHz on 35 RT and 25 CRT patients after 12-month followed up. The hearing loss was evaluated according to the Common Terminology Criteria for Adverse Events (CTCAE) criteria.<bold>Results: </bold>SNHL increased to 84% in patients who had received CRT, compared with 26% increasing in patients who had treated with RT. There was an increased risk of SNHL at all frequencies for ears received a cochlear mean dose >50 Gy in RT group, compared to those receiving cochlear mean dose >30 Gy in CRT group. SNHL was more severe at higher frequencies in both patient groups.<bold>Conclusion: </bold>Characteristic of radiation-induced SNHL is different from CRT-induced SNHL, especially in threshold radiation dose and PTA frequency.
- Subjects
SENSORINEURAL hearing loss; HEAD &; neck cancer; CANCER patients; AUDIOMETRY; RADIATION doses
- Publication
Journal of Cancer Research & Therapeutics, 2020, Vol 16, Issue 3, p539
- ISSN
0973-1482
- Publication type
journal article
- DOI
10.4103/jcrt.JCRT_891_16