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- Title
A pilot study of the impact of Vitamin C supplementation with neoadjuvant chemoradiation on regulators of inflammation and carcinogenesis in esophageal cancer patients.
- Authors
Abdel-Latif, Mohamed M. M.; Babar, Mawash; Reynolds, John V.; Kelleher, Dermot
- Abstract
<bold>Aims: </bold>Vitamin C plays a role in chemoprevention in cancer treatment, and Vitamin C modulates many regulators of inflammation in in vitro studies. The aim of this study is to assess the effect of Vitamin C supplementation with neoadjuvant chemoradiation in esophageal adenocarcinoma on the nuclear factor-kappa B (NF-κB) and associated cytokines.<bold>Materials and Methods: </bold>A total of 20 patients undergoing multimodal treatment for esophageal adenocarcinoma were randomized to receive Vitamin C (1000 mg/day) orally for 4 weeks or no supplementation. Pre- and post-Vitamin C endoscopic biopsies were used for the study of NF-κB activity and cytokine analysis.<bold>Results: </bold>NF-κB activity along with cytokines was activated in the cancer tissue pretreatment. Down-regulation in NF-κB activity was observed in 25% of cases, two from the Vitamin C arm posttreatment. There was a significant reduction in cytokines levels in the cancer group, and this effect was more pronounced in the Vitamin C group (P < 0.05).<bold>Conclusions: </bold>Vitamin C supplementation had a mild protective effect in modulating of regulators of inflammation and carcinogenesis. Further studies with larger numbers of endpoints are needed to evaluate its effect on modulation of chemoradiation responses.
- Subjects
RADIOTHERAPY; VITAMIN C; ESOPHAGEAL cancer patients
- Publication
Journal of Cancer Research & Therapeutics, 2019, Vol 15, Issue 1, p185
- ISSN
0973-1482
- Publication type
journal article
- DOI
10.4103/jcrt.JCRT_763_16