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- Title
Effects of atorvastatin and vitamin E on lipoproteins and oxidative stress in dialysis patients: a randomised-controlled trial.
- Authors
Diepeveen, S. H. A.; Verhoeven, G. W. H. E.; van der Palen, J.; Dikkeschei, L. D.; van Tits, L. J.; Kolsters, G.; Offerman, J. J. G.; Bilo, H. J. G.; Stalenhoef, A. F. H.
- Abstract
Diepeveen SHA, Verhoeven GWHE, van der Palen J, Dikkeschei LD, van Tits LJ, Kolsters G, Offerman JJG, Bilo HJG, Stalenhoef AFH (Isala Clinics, location Weezenlanden, Zwolle; Medical Spectrum Twente, Enschede; and Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands). Effects of atorvastatin and vitamin E on lipoproteins and oxidative stress in dialysis patients: a randomised-controlled trial.J Intern Med2005;257:438–445.The objective of this study was to examine the effects of treatment with atorvastatin,α-tocopherol and the combination of both, on lipoproteins and oxidative stress in dialysis patients.This double-blind randomised placebo-controlled trial was performed at the dialysis department of a non-university hospital.A total of 44 clinically stable, non-diabetic patients on dialysis therapy (23 on haemo- and 21 on peritoneal-dialysis) without manifest cardiovascular disease were included in this study. They were randomised for treatment during a period of 12 weeks with 40 mg atorvastatin + placeboα-tocopherol (group 1) once daily, 800 IUα-tocopherol + placebo atorvastatin once daily (group 2), 40 mg atorvastatin + 800 IUα-tocopherol once daily (group 3), or placebo atorvastatin + placeboα-tocopherol once daily (group 4). Assessment of lipid profile and oxidative stress was performed at the start of the study and after 12 weeks of treatment.Treatment with atorvastatin reduced total cholesterol, triglycerides (TG), low-density lipoprotein (LDL) cholesterol, apolipoprotein B (apoB) and levels of oxidised LDL (oxLDL) with 30–43%. It had no influence on LDL oxidisability. Additional supplementation withα-tocopherol had no effect on lipid profile and oxLDL levels but decreasedin vitroLDL oxidisability. No side-effects were observed.Treatment with atorvastatin is effective in lowering plasma total cholesterol, TG, LDL, apoB and oxLDL in a population of stable dialysis patients and might therefore be an effective tool in improving the poor cardiovascular outcome in these patients. Supplementation ofα-tocopherol to atorvastatin had beneficial effects onin vitroLDL oxidisability and might therefore be of additional value. Further research on the clinical effects of treatment with atorvastatin in combination withα-tocopherol is necessary.
- Subjects
THERAPEUTICS; STATINS (Cardiovascular agents); THERAPEUTIC use of vitamin E; OXIDATIVE stress; LIPOPROTEINS; DIALYSIS (Chemistry)
- Publication
Journal of Internal Medicine, 2005, Vol 257, Issue 5, p438
- ISSN
0954-6820
- Publication type
Article
- DOI
10.1111/j.1365-2796.2005.01484.x