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- Title
The Q/E27 polymorphism in the β<sub>2</sub>-adrenoceptor gene is associated with increased body weight and dyslipoproteinaemia involving triglyceride-rich lipoproteins.
- Authors
Ehrenborg, E.; Skogsberg, J.; Ruotolo, G.; Large, V.; Eriksson, P.; Arner, P.; Hamsten, A.
- Abstract
Abstract. Ehrenborg E, Skogsberg J, Ruotolo G, Large V, Eriksson P, Arner P, Hamsten A (Karolinska Hospital, Stockholm, and Huddinge University Hospital, Huddinge, Sweden; and Istuto Scientifico H San Raffaele, Milano, Italy). The Q/E27 polymorphism in the β2-adrenoceptor gene is associated with increased body weight and dyslipoproteinaemia involving triglyceride-rich lipoproteins. J Intern Med 2000; 247: 651–656. Objectives. To investigate whether a substitution of glutamine by glutamic acid at amino acid position 27 (Q/E27) and an arginine to glycine transition at amino acid 16 (R/G16) in the β2-adrenoceptor gene are associated with lipid and lipoprotein disturbances and/or increased body weight in men. Design. Population-based study. Setting. Department of medicine at a university hospital. Subjects. A total of 180 healthy men, aged 30–45 years, were recruited at random from a register containing all permanent residents in Stockholm County (response rate of 70%). Main outcome measures. Frequency of β2-adrenoceptor genotypes and alleles in relation to plasma lipid and lipoprotein levels and body mass index. Results. Individuals carrying the E27 allele and/or the G16 allele had significantly higher body mass index (BMI). Furthermore, carriers of the E27 allele had significantly higher plasma concentrations of cholesterol, triglycerides, VLDL cholesterol and VLDL triglycerides than did subjects homozygous for the Q allele. Conclusion. The E27 allele of the β2-adrenoceptor gene is associated with slightly to moderately elevated BMI and dyslipoproteinaemia involving triglyceride-rich lipoproteins in healthy younger and middle-aged men.
- Subjects
BODY weight; OBESITY genetics; LOW density lipoproteins; MEN'S health; PHYSIOLOGY
- Publication
Journal of Internal Medicine, 2000, Vol 247, Issue 6, p651
- ISSN
0954-6820
- Publication type
Article
- DOI
10.1046/j.1365-2796.2000.00669.x