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- Title
TNF-α Polymorphisms in Primary Biliary Cirrhosis: A Northern and Southern Italian Experience.
- Authors
Niro, Grazia Anna; Poli, Francesca; Andriulli, Angelo; Bianchi, Ilaria; Bernuzzi, Francesca; Caliari, Lisa; Fontana, Rosanna; Gioffreda, Domenica; Valvano, Maria Rosa; Podda, Mauro; Invernizzi, Pietro
- Abstract
Specific HLA alleles and immunoregulatory genes have been evaluated in primary biliary cirrhosis (PBC), but data are discordant. We determined whether TNF-α promoter polymorphisms (G-308A and G-238A) and alleles of HLA class II (HLA-DRB1) might be associated either with PBC occurrence and severity in Italian populations from two distinct areas. The distribution of TNF1 (G/G) genotype did not differ either between patients and controls or between patients from Northern and Southern Italy. Contrariwise, the HLA-DRB1*08 appeared positively linked to the occurrence of disease (8.4% in patients vs. 2.5% in controls, P= 0.003), whereas the HLA-DRB1*13 appeared to be protective, being more frequent in controls (12.8%) than in patients (7%) ( P= 0.038). Neither positively nor negatively associated alleles of the two genomic loci had an effect on disease progression. We report a distinct genetic risk of developing PBC in the Italian population, with no interaction between the HLA and TNF alleles.
- Subjects
ITALY; CIRRHOSIS of the liver; PATIENTS; GENETIC polymorphisms; BILIARY tract
- Publication
Annals of the New York Academy of Sciences, 2009, Vol 1173, p557
- ISSN
0077-8923
- Publication type
Article
- DOI
10.1111/j.1749-6632.2009.04741.x